Gene
col8a2
- ID
- ZDB-GENE-060503-488
- Name
- collagen, type VIII, alpha 2
- Symbol
- col8a2 Nomenclature History
- Previous Names
-
- si:ch211-197n10.4
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to be an extracellular matrix structural constituent conferring tensile strength. Predicted to be involved in extracellular matrix organization. Predicted to be located in extracellular region. Predicted to be part of collagen trimer. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in bone tissue. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy and posterior polymorphous corneal dystrophy 2. Orthologous to human COL8A2 (collagen type VIII alpha 2 chain).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Xiong et al., 2017
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Fuchs' endothelial dystrophy | Alliance | Corneal dystrophy, Fuchs endothelial, 1 | 136800 |
| posterior polymorphous corneal dystrophy 2 | Alliance | Corneal dystrophy, posterior polymorphous 2 | 609140 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | C1q domain | Collagen and Collagen-like Structural Proteins | Collagen triple helix repeat | Tumour necrosis factor-like domain superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:Q1LUA9 | InterPro | 686 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
col8a2-201
(1)
|
Ensembl | 3,045 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-197N10 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001082901 (1) | 3045 nt | ||
| Genomic | GenBank:BX957241 (1) | 199001 nt | ||
| Polypeptide | UniProtKB:Q1LUA9 (1) | 686 aa |
- Debiais-Thibaud, M., Simion, P., Ventéo, S., Muñoz, D., Marcellini, S., Mazan, S., Haitina, T. (2019) Skeletal mineralisation in association with type X collagen expression is an ancestral feature for jawed vertebrates. Molecular Biology and Evolution. 36(10):2265-2276
- Huang, V., Butler, A.A., Lubin, F.D. (2019) Telencephalon transcriptome analysis of chronically stressed adult zebrafish. Scientific Reports. 9:1379
- Boskovic, S., Marín-Juez, R., Jasnic, J., Reischauer, S., El Sammak, H., Kojic, A., Faulkner, G., Radojkovic, D., Stainier, D.Y.R., Kojic, S. (2018) Characterization of zebrafish (Danio rerio) muscle ankyrin repeat proteins reveals their conserved response to endurance exercise. PLoS One. 13:e0204312
- Bretaud, S., Nauroy, P., Malbouyres, M., Ruggiero, F. (2018) FISHING FOR COLLAGEN FUNCTION: ABOUT DEVELOPMENT, REGENERATION AND DISEASE. Seminars in cell & developmental biology. 89:100-108
- Sánchez-Iranzo, H., Galardi-Castilla, M., Sanz-Morejón, A., González-Rosa, J.M., Costa, R., Ernst, A., Sainz de Aja, J., Langa, X., Mercader, N. (2018) Transient fibrosis resolves via fibroblast inactivation in the regenerating zebrafish heart. Proceedings of the National Academy of Sciences of the United States of America. 115(16):4188-4193
- Díaz-Pascual, F., Ortíz-Severín, J., Varas, M.A., Allende, M.L., Chávez, F.P. (2017) In vivo Host-Pathogen Interaction as Revealed by Global Proteomic Profiling of Zebrafish Larvae.. Frontiers in cellular and infection microbiology. 7:334
- Xiong, S., Wu, J, Jing, J., Huang, P., Li, Z., Mei, J., Gui, J.F, (2017) Loss of stat3 function leads to spine malformation and immune disorder in zebrafish. Science Bulletin. 62:Pages 185-196
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Zhang, H., Wang, X., Lv, K., Gao, S., Wang, G., Fan, C., Zhang, X.A., Yan, J. (2015) Time Point-based Integrative Analyses of Deep-transcriptome Identify Four Signal Pathways in Blastemal Regeneration of Zebrafish Lower Jaw. Stem cells (Dayton, Ohio). 33(3):806-18
- Cannon, J.E., Place, E.S., Eve, A.M., Bradshaw, C.R., Sesay, A., Morrell, N.W., and Smith, J.C. (2013) Global analysis of the haematopoietic and endothelial transcriptome during zebrafish development. Mechanisms of Development. 130(2-3):122-131
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