ZFIN is now using GRCz12tu for Genomic Data
Gene
ptpn22
- ID
- ZDB-GENE-060503-458
- Name
- protein tyrosine phosphatase non-receptor type 22
- Symbol
- ptpn22 Nomenclature History
- Previous Names
-
- si:dkey-78k11.1
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in several processes, including T cell receptor signaling pathway; negative regulation of T cell activation; and regulation of non-canonical NF-kappaB signal transduction. Predicted to be active in cytoplasm and nucleus. Is expressed in heart and heart tube. Human ortholog(s) of this gene implicated in several diseases, including arthritis (multiple); autoimmune disease of endocrine system (multiple); autoimmune disease of musculoskeletal system (multiple); autoimmune disease of the nervous system (multiple); and vasculitis (multiple). Orthologous to human PTPN22 (protein tyrosine phosphatase non-receptor type 22).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Ma et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR016130 | Protein-tyrosine phosphatase, active site |
| Domain | IPR000242 | Tyrosine-specific protein phosphatase, PTPase domain |
| Domain | IPR000387 | Tyrosine-specific protein phosphatases domain |
| Domain | IPR003595 | Protein-tyrosine phosphatase, catalytic |
| Family | IPR047170 | Tyrosine-protein phosphatase non-receptor type 12/18/22 |
| Homologous_superfamily | IPR029021 | Protein-tyrosine phosphatase-like |
Domain Details Per Protein
| Protein | Additional Resources | Length | Protein-tyrosine phosphatase, active site | Protein-tyrosine phosphatase, catalytic | Protein-tyrosine phosphatase-like | Tyrosine-protein phosphatase non-receptor type 12/18/22 | Tyrosine-specific protein phosphatase, PTPase domain | Tyrosine-specific protein phosphatases domain |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2B909 | InterPro | 886 | ||||||
| UniProtKB:A5D6T3 | InterPro | 887 | ||||||
| UniProtKB:A0A8M2B913 | InterPro | 882 | ||||||
| UniProtKB:A0AC58IKC5 | InterPro | 901 | ||||||
| UniProtKB:A0AC58IKF8 | InterPro | 895 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ptpn22-201
(1)
|
Ensembl | 2,664 nt | ||
| mRNA |
ptpn22-202
(1)
|
Ensembl | 585 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers