Gene
cactin
- ID
- ZDB-GENE-060503-322
- Name
- cactin
- Symbol
- cactin Nomenclature History
- Previous Names
-
- si:ch211-281o21.6 (1)
- si:dkey-158a20.4
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Involved in anterior/posterior axis specification, embryo; eye development; and positive regulation of embryonic development. Acts upstream of or within neural retina development. Predicted to be located in nucleus. Predicted to be part of spliceosomal complex. Predicted to be active in cytoplasm. Is expressed in eye; immature eye; and tail bud. Orthologous to human CACTIN (cactin, spliceosome C complex subunit).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Atzei et al., 2010
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Atzei et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa33034 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Splicing factor cactin, central domain | Splicing factor Cactin, C-terminal |
|---|---|---|---|---|
| UniProtKB:F1Q8W0 | InterPro | |||
| UniProtKB:A0A8M2BFR6 | InterPro | 836 | ||
| UniProtKB:A0AB13ABM1 | InterPro | 835 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cactin-201
(1)
|
Ensembl | 3,139 nt | ||
| mRNA |
cactin-202
(1)
|
Ensembl | 823 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-209F23 | ZFIN Curated Data | |
| Contained in | BAC | CH211-281O21 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-158A20 | ZFIN Curated Data | |
| Has Artifact | cDNA | MGC:158620 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001423826 (1) | 3186 nt | ||
| Genomic | GenBank:CR926137 (1) | 184144 nt | ||
| Polypeptide | UniProtKB:A0A8M2BFR6 (1) | 836 aa |
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Atzei, P., Yang, F., Collery, R., Kennedy, B.N., and Moynagh, P.N. (2010) Characterisation of expression patterns and functional role of Cactin in early zebrafish development. Gene expression patterns : GEP. 10(4-5):199-206
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