Gene

wdr62

ID
ZDB-GENE-060503-291
Name
WD repeat domain 62
Symbol
wdr62 Nomenclature History
Previous Names
  • fa11h05
  • fb33e12
  • si:ch211-152c12.2
  • wu:fa11h05
  • wu:fb33e12
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Acts upstream of or within heart development. Predicted to be active in mitotic spindle. Used to study microcephaly. Human ortholog(s) of this gene implicated in intellectual disability; polymicrogyria; primary autosomal recessive microcephaly; and primary autosomal recessive microcephaly 2 with or without cortical malformations. Orthologous to human WDR62 (WD repeat domain 62).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
la027663TgTransgenic insertionUnknownUnknownDNA
sa5875Allele with one point mutationUnknownPremature StopENU
sa8577Allele with one point mutationUnknownPremature StopENU
sa11070Allele with one point mutationUnknownPremature StopENU
sa16137Allele with one point mutationUnknownPremature StopENU
sa22583Allele with one point mutationUnknownSplice SiteENU
sa28400Allele with one point mutationUnknownPremature StopENU
ulb11Allele with one deletionExon 1UnknownTALEN
ulb12Allele with one deletionExon 1UnknownTALEN
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Sequence Targeting Reagents
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Human Disease
Associated With wdr62 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
primary autosomal recessive microcephaly 2 with or without cortical malformations Alliance Microcephaly 2, primary, autosomal recessive, with or without cortical malformations 604317
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Associated With wdr62 Via Experimental Models
Human Disease Fish Conditions Citations
microcephaly WT + MO1-wdr62 standard conditions Novorol et al., 2013
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Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR056161 MABP1/WDR62, first WD40 domain
Domain IPR056162 MABP1/WDR62, second WD40 domain
Family IPR055292 Mitogen-activated protein kinase-binding protein 1
Homologous_superfamily IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily
Homologous_superfamily IPR015943 WD40/YVTN repeat-like-containing domain superfamily
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Domain Details Per Protein
Protein Additional Resources Length MABP1/WDR62, first WD40 domain MABP1/WDR62, second WD40 domain Mitogen-activated protein kinase-binding protein 1 Quinoprotein alcohol dehydrogenase-like superfamily WD40 repeat WD40-repeat-containing domain superfamily WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:F6NPK9 InterPro 1493
UniProtKB:A0A8M2BH37 InterPro 1492
UniProtKB:A0A286YBK5 InterPro 1519
UniProtKB:A0A8M2BGZ4 InterPro 1518
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 15
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA wdr62-201 (1) Ensembl 5,204 nt
mRNA wdr62-202 (1) Ensembl 758 nt
mRNA wdr62-203 (1) Ensembl 5,732 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-152C12ZFIN Curated Data
ContainsSNPrs3728690
    ZFIN Curated Data
    ContainsSNPrs3728691
      ZFIN Curated Data
      EncodesESTfa11h05
      EncodesESTfb33e12
      EncodescDNAMGC:195119ZFIN Curated Data
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      Sequences
      Orthology
      Comparative Orthology
      Alliance
      Gene Tree
      Ensembl
      Species Symbol Chromosome Accession # Evidence
      HumanWDR6219
      Functional complementation (1)
      Amino acid sequence comparison (2)
      Conserved genome location (synteny) (1)
      MouseWdr627
      Amino acid sequence comparison (1)
      Conserved genome location (synteny) (1)
      Citations
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