Gene
wdr62
- ID
- ZDB-GENE-060503-291
- Name
- WD repeat domain 62
- Symbol
- wdr62 Nomenclature History
- Previous Names
-
- fa11h05
- fb33e12
- si:ch211-152c12.2
- wu:fa11h05
- wu:fb33e12
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Acts upstream of or within heart development. Predicted to be active in mitotic spindle. Used to study microcephaly. Human ortholog(s) of this gene implicated in intellectual disability; polymicrogyria; primary autosomal recessive microcephaly; and primary autosomal recessive microcephaly 2 with or without cortical malformations. Orthologous to human WDR62 (WD repeat domain 62).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary autosomal recessive microcephaly 2 with or without cortical malformations | Alliance | Microcephaly 2, primary, autosomal recessive, with or without cortical malformations | 604317 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| microcephaly | WT + MO1-wdr62 | standard conditions | Novorol et al., 2013 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR056161 | MABP1/WDR62, first WD40 domain |
| Domain | IPR056162 | MABP1/WDR62, second WD40 domain |
| Family | IPR055292 | Mitogen-activated protein kinase-binding protein 1 |
| Homologous_superfamily | IPR011047 | Quinoprotein alcohol dehydrogenase-like superfamily |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
| Repeat | IPR001680 | WD40 repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | MABP1/WDR62, first WD40 domain | MABP1/WDR62, second WD40 domain | Mitogen-activated protein kinase-binding protein 1 | Quinoprotein alcohol dehydrogenase-like superfamily | WD40 repeat | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F6NPK9 | InterPro | 1493 | |||||||
| UniProtKB:A0A8M2BH37 | InterPro | 1492 | |||||||
| UniProtKB:A0A286YBK5 | InterPro | 1519 | |||||||
| UniProtKB:A0A8M2BGZ4 | InterPro | 1518 |
Interactions and Pathways
No data available
Plasmids
No data available