Gene
tulp4a
- ID
- ZDB-GENE-060503-215
- Name
- TUB like protein 4a
- Symbol
- tulp4a Nomenclature History
- Previous Names
-
- tulp4
- fb99g11
- si:ch211-222h17.4
- si:ch211-51e12.5
- wu:fb75h04
- wu:fb99g11
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to be involved in protein ubiquitination. Predicted to be located in cytoplasm. Orthologous to human TULP4 (TUB like protein 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la024685Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la024717Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa12777 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa18049 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20166 | Allele with one point mutation | Unknown | Missense, Splice Site | ENU | |
| sa20167 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33350 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-tulp4a | N/A | McKinney-Freeman et al., 2012 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | AH/BAR domain superfamily | SOCS box domain | Tubby, C-terminal | Tubby-like, C-terminal | WD40 repeat | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily | WDR35/TULP4, N-terminal |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F6NJC6 | InterPro | 1736 | ||||||||
| UniProtKB:A0A8M6YZI4 | InterPro | 1727 | ||||||||
| UniProtKB:E7EXF2 | InterPro | 1639 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tulp4a-201
(1)
|
Ensembl | 5,119 nt | ||
| mRNA |
tulp4a-202
(1)
|
Ensembl | 6,019 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-51E12 | ZFIN Curated Data | |
| Contained in | BAC | CH211-222H17 | ZFIN Curated Data | |
| Encodes | EST | fb75h04 | ZFIN Curated Data | |
| Encodes | EST | fb99g11 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001045095 (1) | 5119 nt | ||
| Genomic | GenBank:BX890562 (1) | 195554 nt | ||
| Polypeptide | UniProtKB:F6NJC6 (1) | 1736 aa |
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- McKinney-Freeman, S., Cahan, P., Li, H., Lacadie, S.A., Huang, H.T., Curran, M., Loewer, S., Naveiras, O., Kathrein, K.L., Konantz, M., Langdon, E.M., Lengerke, C., Zon, L.I., Collins, J.J., and Daley, G.Q. (2012) The transcriptional landscape of hematopoietic stem cell ontogeny. Cell Stem Cell. 11(5):701-714
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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