Gene

brat1

ID

ZDB-GENE-060421-6989

Name

BRCA1-associated ATM activator 1

Symbol

brat1 Nomenclature History

Previous Names

zgc:136845

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to enable ribonuclease inhibitor activity. Predicted to be involved in several processes, including integrator complex assembly; positive regulation of protein phosphorylation; and response to ionizing radiation. Predicted to act upstream of or within cell population proliferation. Predicted to be active in cytoplasm and nucleus. Orthologous to human BRAT1 (BRCA1 associated ATM activator 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Livne et al., 2022

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With brat1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Neurodevelopmental disorder with cerebellar atrophy and with or without seizures	618056
		Rigidity and multifocal seizure syndrome, lethal neonatal	614498

Associated With brat1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR038904	BRCA1-associated ATM activator 1
Homologous_superfamily	IPR011989	Armadillo-like helical
Homologous_superfamily	IPR016024	Armadillo-type fold