Gene
cog4
- ID
- ZDB-GENE-060312-33
- Name
- component of oligomeric golgi complex 4
- Symbol
- cog4 Nomenclature History
- Previous Names
-
- zgc:136860
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to be involved in Golgi organization; Golgi vesicle prefusion complex stabilization; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to localize to Golgi transport complex. Used to study Saul-Wilson syndrome. Human ortholog(s) of this gene implicated in Saul-Wilson syndrome and congenital disorder of glycosylation type IIj. Is expressed in nervous system; otic epithelium; otic vesicle protrusion; and pharyngeal arch cartilage. Orthologous to human COG4 (component of oligomeric golgi complex 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 13 figures from 2 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital disorder of glycosylation type IIj | Alliance | Congenital disorder of glycosylation, type IIj | 613489 |
| Saul-Wilson syndrome | Alliance | Saul-Wilson syndrome | 618150 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| Saul-Wilson syndrome | cog4b1312/b1312 | standard conditions | Ferreira et al., 2018 |
| Saul-Wilson syndrome | cog4b1311/b1311 | standard conditions | Ferreira et al., 2018 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR013167 | COG4 transport protein, middle alpha-helical bundle |
| Domain | IPR048680 | Conserved oligomeric Golgi complex subunit 4, N-terminal |
| Domain | IPR048684 | Conserved oligomeric Golgi complex subunit 4, C-terminal |
| Family | IPR048682 | Conserved oligomeric Golgi complex subunit 4 |
Domain Details Per Protein
| Protein | Length | COG4 transport protein, middle alpha-helical bundle | Conserved oligomeric Golgi complex subunit 4 | Conserved oligomeric Golgi complex subunit 4, C-terminal | Conserved oligomeric Golgi complex subunit 4, N-terminal |
|---|---|---|---|---|---|
|
UniProtKB:Q29RB1
|
781 |
Interactions and Pathways
No data available
Plasmids
No data available