Gene

roraa

ID
ZDB-GENE-060306-2
Name
RAR-related orphan receptor A, paralog a
Symbol
roraa Nomenclature History
Previous Names
  • rora2 (1)
  • rora
  • gb:dq017624
  • NR1F1-B (1)
  • RORalpha-B (1)
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Predicted to have several functions, including nuclear receptor activity; steroid hormone receptor activity; and zinc ion binding activity. Involved in cerebellum morphogenesis and positive regulation of gene expression. Predicted to localize to nucleus. Is expressed in brain and eye. Orthologous to human RORA (RAR related orphan receptor A).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
19 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Guissart et al., 2018
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With roraa Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Intellectual developmental disorder with or without epilepsy or cerebellar ataxia 618060
Associated With roraa Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000536 Nuclear hormone receptor, ligand-binding domain
Domain IPR001628 Zinc finger, nuclear hormone receptor-type
Domain IPR044101 Retinoid-related orphan receptors, DNA-binding domain
Family IPR001723 Nuclear hormone receptor
Family IPR003079 Nuclear receptor ROR
Homologous_superfamily IPR013088 Zinc finger, NHR/GATA-type
Homologous_superfamily IPR035500 Nuclear hormone receptor-like domain superfamily
Domain Details Per Protein
Protein Length Nuclear hormone receptor Nuclear hormone receptor, ligand-binding domain Nuclear hormone receptor-like domain superfamily Nuclear receptor ROR Retinoid-related orphan receptors, DNA-binding domain Zinc finger, NHR/GATA-type Zinc finger, nuclear hormone receptor-type
UniProtKB:Q1L682 229
UniProtKB:F1QLY4 468
UniProtKB:A0A5H1ZRI7 458
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations