Gene
grm2b
- ID
- ZDB-GENE-060201-5
- Name
- glutamate receptor, metabotropic 2b
- Symbol
- grm2b Nomenclature History
- Previous Names
-
- grm2
- gb:kf234084
- mglur2b (1)
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable group II metabotropic glutamate receptor activity. Predicted to be involved in G protein-coupled glutamate receptor signaling pathway and regulation of glutamatergic synaptic transmission. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in brain. Orthologous to human GRM2 (glutamate metabotropic receptor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Haug et al., 2013
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017979 | GPCR, family 3, conserved site |
| Domain | IPR001828 | Receptor, ligand binding region |
| Domain | IPR011500 | GPCR, family 3, nine cysteines domain |
| Domain | IPR017978 | GPCR family 3, C-terminal |
| Family | IPR000162 | GPCR, family 3, metabotropic glutamate receptor |
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Domain Details Per Protein
| Protein | Additional Resources | Length | GPCR, family 3 | GPCR, family 3, conserved site | GPCR family 3, C-terminal | GPCR, family 3, metabotropic glutamate receptor | GPCR, family 3, metabotropic glutamate receptor 2 | GPCR, family 3, nine cysteines domain | GPCR, family 3, nine cysteines domain superfamily | Metabotropic Glutamate Receptor | Periplasmic binding protein-like I | Receptor, ligand binding region |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:E7F7E9 | InterPro | 874 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-213O11 | ZFIN Curated Data | |
| Contained in | BAC | CH211-288H8 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-51M8 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001287547 (1) | 2664 nt | ||
| Genomic | GenBank:BX248230 (1) | 217432 nt | ||
| Polypeptide | UniProtKB:E7F7E9 (1) | 874 aa |
- Comparative Orthology
- Alliance
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Coppola, U., Annona, G., D'Aniello, S., Ristoratore, F. (2016) Rab32 and Rab38 genes in chordate pigmentation: an evolutionary perspective. BMC Evolutionary Biology. 16:26
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Haug, M.F., Gesemann, M., Mueller, T., and Neuhauss, S.C. (2013) Phylogeny and expression divergence of metabotropic glutamate receptor genes in the brain of zebrafish (Danio rerio). The Journal of comparative neurology. 521(7):1533-1560
- Bjarnadottir, T.K., Fredriksson, R., and Schioth, H.B. (2005) The gene repertoire and the common evolutionary history of glutamate, pheromone (V2R), taste(1) and other related G protein-coupled receptors. Gene. 362C:70-84
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