Gene

ar

ID
ZDB-GENE-060131-1
Name
androgen receptor
Symbol
ar Nomenclature History
Previous Names
  • Ar beta (1)
  • AR-A (1)
  • NR3C4 (1)
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Exhibits androgen binding activity; nuclear receptor activity; and steroid hormone receptor activity. Involved in gamete generation; male courtship behavior; and male gonad development. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; conduct disorder; disorders of sexual development (multiple); reproductive organ cancer (multiple); and spinal muscular atrophy (multiple). Is expressed in several structures, including digestive system; heart; male organism; nervous system; and pleuroperitoneal region. Orthologous to human AR (androgen receptor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
28 figures from 15 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
26 figures from 6 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ar Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
androgen insensitivity syndrome Alliance Androgen insensitivity 300068
hypogonadism Alliance Androgen insensitivity, partial, with or without breast cancer 312300
hypospadias Alliance Hypospadias 1, X-linked 300633
Kennedy's disease Alliance Spinal and bulbar muscular atrophy of Kennedy 313200
partial androgen insensitivity syndrome Alliance Androgen insensitivity, partial, with or without breast cancer 312300
prostate cancer Alliance {Prostate cancer, susceptibility to} 176807
Associated With ar Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000536 Nuclear hormone receptor, ligand-binding domain
Domain IPR001628 Zinc finger, nuclear hormone receptor-type
Family IPR001723 Nuclear hormone receptor
Homologous_superfamily IPR013088 Zinc finger, NHR/GATA-type
Homologous_superfamily IPR035500 Nuclear hormone receptor-like domain superfamily
Domain Details Per Protein
Protein Length Nuclear hormone receptor Nuclear hormone receptor, ligand-binding domain Nuclear hormone receptor-like domain superfamily Zinc finger, NHR/GATA-type Zinc finger, nuclear hormone receptor-type
UniProtKB:Q6EAL5 377
UniProtKB:A4GVF3 868
UniProtKB:A4GT83 868
UniProtKB:B3GN41 868
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations