Gene
slc8a1b
- ID
- ZDB-GENE-060110-3
- Name
- solute carrier family 8 member 1b
- Symbol
- slc8a1b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable calcium:sodium antiporter activity. Acts upstream of or within enteric nervous system development. Predicted to be located in endomembrane system and plasma membrane. Predicted to be active in axon; postsynapse; and sarcolemma. Is expressed in several structures, including blood; eye; liver; neural tube; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human SLC8A1 (solute carrier family 8 member A1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa19172 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa23060 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa23061 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa28843 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa36395 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Calcium/Cation Antiporter | CalX-like domain superfamily | DnaJ domain | Na-Ca exchanger/integrin-beta4 | NCX, central ion-binding domain superfamily | Sodium/calcium exchanger domain, C-terminal extension | Sodium/calcium exchanger membrane region | Sodium/calcium exchanger protein |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:B2CZC2 | InterPro | 942 | ||||||||
| UniProtKB:A0A8M9P932 | InterPro | 310 | ||||||||
| UniProtKB:Q32SG7 | InterPro | 944 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc8a1b-201
(1)
|
Ensembl | 2,835 nt | ||
| mRNA |
slc8a1b-202
(1)
|
Ensembl | 4,238 nt | ||
| mRNA |
slc8a1b-203
(1)
|
Ensembl | 2,955 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-215M14 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-37K14 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194875 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001039144 (1) | 2835 nt | ||
| Genomic | GenBank:AL772132 (1) | 205802 nt | ||
| Polypeptide | UniProtKB:Q32SG7 (1) | 944 aa |
- Abu Obaid, A., Ivandic, I., Korsching, S.I. (2024) Deciphering the function of the fifth class of Gα proteins: regulation of ionic homeostasis as unifying hypothesis. Cellular and molecular life sciences : CMLS. 81:213213
- Whyte-Fagundes, P., Taskina, D., Safarian, N., Zoidl, C., Carlen, P.L., Donaldson, L.W., Zoidl, G.R. (2022) Panx1 channels promote both anti- and pro-seizure-like activities in the zebrafish via p2rx7 receptors and ATP signaling. Communications biology. 5:472
- Kuil, L.E., MacKenzie, K.C., Tang, C.S., Windster, J.D., Le, T.L., Karim, A., de Graaf, B.M., van der Helm, R., van Bever, Y., Sloots, C.E.J., Meeussen, C., Tibboel, D., de Klein, A., Wijnen, R.M.H., Amiel, J., Lyonnet, S., Garcia-Barcelo, M.M., Tam, P.K.H., Alves, M.M., Brooks, A.S., Hofstra, R.M.W., Brosens, E. (2021) Size matters: Large copy number losses in Hirschsprung disease patients reveal genes involved in enteric nervous system development. PLoS Genetics. 17:e1009698
- Lee, C.Y., Horng, J.L., Liu, S.T., Lin, L.Y. (2020) Exposure to copper nanoparticles impairs ion uptake, and acid and ammonia excretion by ionocytes in zebrafish embryos. Chemosphere. 261:128051
- Tong, S.K., Lee, H.L., Lee, Y.C., Wu, L.C., Tsou, Y.L., Lu, S.W., Shih, S.W., Hwang, P.P., Chou, M.Y. (2020) Arginine Vasopressin Modulates Ion and Acid/Base Balance by Regulating Cell Numbers of Sodium Chloride Cotransporter and H+-ATPase Rich Ionocytes. International Journal of Molecular Sciences. 21(11)
- Giffen, K.P., Liu, H., Kramer, K.L., He, D.Z. (2019) Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Frontiers in neuroscience. 13:1117
- Dragojević, J., Mihaljević, I., Popović, M., Zaja, R., Smital, T. (2018) In vitro characterization of zebrafish (Danio rerio) organic anion transporters Oat2a-e. Toxicology in vitro : an international journal published in association with BIBRA. 46:246-256
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Nagata, Y., Yamagishi, M., Konno, T., Nakanishi, C., Asano, Y., Ito, S., Nakajima, Y., Seguchi, O., Fujino, N., Kawashiri, M.A., Takashima, S., Kitakaze, M., Hayashi, K. (2017) Heat Failure Phenotypes Induced by Knockdown of DAPIT in Zebrafish: A New Insight into Mechanism of Dilated Cardiomyopathy. Scientific Reports. 7:17417
- Pillar, N., Pleniceanu, O., Fang, M., Ziv, L., Lahav, E., Botchan, S., Cheng, L., Dekel, B., Shomron, N. (2017) A rare variant in the FHL1 gene associated with X-linked recessive hypoparathyroidism. Human genetics. 136(7):835-845
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