Gene

slc8a4a

ID
ZDB-GENE-060110-2
Name
solute carrier family 8 member 4a
Symbol
slc8a4a Nomenclature History
Previous Names
  • ncx4a (2)
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Enables calcium:sodium antiporter activity. Involved in calcium ion import across plasma membrane and sodium ion transmembrane transport. Acts upstream of or within several processes, including heart contraction; heart looping; and skeletal muscle tissue development. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in several structures, including Kupffer's vesicle; blood; digestive system; muscle; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human SLC8A1 (solute carrier family 8 member A1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With slc8a4a Human Ortholog
No data available
Associated With slc8a4a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003644 Na-Ca exchanger/integrin-beta4
Domain IPR004837 Sodium/calcium exchanger membrane region
Domain IPR032452 Sodium/calcium exchanger domain, C-terminal extension
Family IPR004836 Sodium/calcium exchanger protein
Homologous_superfamily IPR038081 CalX-like domain superfamily
Domain Details Per Protein
Protein Length CalX-like domain superfamily Na-Ca exchanger/integrin-beta4 Sodium/calcium exchanger domain, C-terminal extension Sodium/calcium exchanger membrane region Sodium/calcium exchanger protein
UniProtKB:A4UQV6 939
UniProtKB:B3DJ26 939
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations