Gene
slc8a4a
- ID
- ZDB-GENE-060110-2
- Name
- solute carrier family 8 member 4a
- Symbol
- slc8a4a Nomenclature History
- Previous Names
-
- ncx4a (2)
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Exhibits calcium:sodium antiporter activity. Involved in several processes, including heart contraction; heart looping; and skeletal muscle tissue development. Predicted to localize to membrane. Human ortholog(s) of this gene implicated in hypertension. Is expressed in several structures, including Kupffer's vesicle; blood; digestive system; muscle; and pleuroperitoneal region. Orthologous to human SLC8A1 (solute carrier family 8 member A1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003644 | Na-Ca exchanger/integrin-beta4 |
| Domain | IPR004837 | Sodium/calcium exchanger membrane region |
| Domain | IPR032452 | Sodium/calcium exchanger domain, C-terminal extension |
| Family | IPR004836 | Sodium/calcium exchanger protein |
| Homologous_superfamily | IPR038081 | CalX-like domain superfamily |
| Homologous_superfamily | IPR044880 | NCX, central ion-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | CalX-like domain superfamily | Na-Ca exchanger/integrin-beta4 | NCX, central ion-binding domain superfamily | Sodium/calcium exchanger domain, C-terminal extension | Sodium/calcium exchanger membrane region | Sodium/calcium exchanger protein |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A4UQV6
|
939 |
| Type | Name | Annotation Method | Length (nt) | Analysis |
|---|---|---|---|---|
| mRNA |
slc8a4a-202
(1)
|
Havana | 4448 nt |
Interactions and Pathways
No data available
Plasmids
No data available