Gene
ppox
- ID
- ZDB-GENE-051120-90
- Name
- protoporphyrinogen oxidase
- Symbol
- ppox Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to have oxygen-dependent protoporphyrinogen oxidase activity. Predicted to be involved in heme biosynthetic process. Predicted to localize to intrinsic component of mitochondrial inner membrane. Used to study variegate porphyria. Human ortholog(s) of this gene implicated in variegate porphyria. Is expressed in blood cell; intermediate cell mass of mesoderm; and lateral plate mesoderm. Orthologous to human PPOX (protoporphyrinogen oxidase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Dooley et al., 2008
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| variegate porphyria | Alliance | Variegate porphyria | 176200 |
| Variegate porphyria, childhood-onset | 620483 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| variegate porphyria | ppoxt23572/t23572 (TU) | standard conditions | Dooley et al., 2008 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Amine oxidase | FAD/NAD(P)-binding domain superfamily | Protoporphyrinogen oxidase |
|---|---|---|---|---|
|
UniProtKB:Q32LU4
|
477 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available