ZFIN is now using GRCz12tu for Genomic Data
Gene
mmd
- ID
- ZDB-GENE-051120-39
- Name
- monocyte to macrophage differentiation-associated
- Symbol
- mmd Nomenclature History
- Previous Names
-
- PAQR11 (1)
- zgc:123296
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable metal ion binding activity. Acts upstream of or within atrioventricular canal development; endocardial cushion formation; and regulation of Ras protein signal transduction. Predicted to be located in endomembrane system and membrane. Is expressed in several structures, including cardiovascular system; nervous system; notochord; pectoral fin; and ventral mesoderm. Orthologous to human MMD (monocyte to macrophage differentiation associated).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Huang et al., 2012
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Huang et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-mmd | N/A | Huang et al., 2012 |
| MO2-mmd | N/A | Huang et al., 2012 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | AdipoR/Haemolysin-III-related | Hly-III |
|---|---|---|---|---|
| UniProtKB:Q32LT2 | InterPro | 239 | ||
| UniProtKB:A0AB13AB76 | InterPro | 240 | ||
| UniProtKB:A0A8M1N841 | InterPro | 239 | ||
| UniProtKB:A0AB32TE76 | InterPro | 215 | ||
| UniProtKB:A0AB32THY9 | InterPro | 200 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Encodes | cDNA | MGC:123296 | ZFIN Curated Data |
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- Genome Browsers
| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001423757 (1) | 6094 nt | ||
| Genomic | GenBank:JBMGRA010000003 (1) | |||
| Polypeptide | UniProtKB:A0AB13AB76 (1) | 240 aa |
- Wright, K., de Silva, K., Plain, K.M., Purdie, A.C., Blair, T.A., Duggin, I.G., Britton, W.J., Oehlers, S.H. (2021) Mycobacterial infection-induced miR-206 inhibits protective neutrophil recruitment via the CXCL12/CXCR4 signalling axis. PLoS pathogens. 17:e1009186
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Huang, H., Jin, T., He, J., Ding, Q., Xu, D., Wang, L., Zhang, Y., Pan, Y., Wang, Z., and Chen, Y. (2012) Progesterone and AdipoQ Receptor 11 Links Ras Signaling to Cardiac Development in Zebrafish. Arterioscler. Thromb. Vasc. Biol.. 32(9):2158-2170
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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