Gene
ahrra
- ID
- ZDB-GENE-051018-1
- Name
- aryl-hydrocarbon receptor repressor a
- Symbol
- ahrra Nomenclature History
- Previous Names
-
- ahrr1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Enables DNA binding activity. Acts upstream of or within cellular response to xenobiotic stimulus and regulation of transcription by RNA polymerase II. Located in nucleus. Orthologous to human AHRR (aryl hydrocarbon receptor repressor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Aryl hydrocarbon receptor/Aryl hydrocarbon receptor repressor | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain | PAS domain | PAS domain superfamily | PAS fold |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q3T2L3 | InterPro | 550 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001035265 (1) | 2434 nt | ||
| Genomic | GenBank:CABZ01084748 (1) | 7938 nt | ||
| Polypeptide | UniProtKB:Q3T2L3 (1) | 550 aa |
- Chen, F., Pu, S., Tian, L., Zhang, H., Zhou, H., Yan, Y., Hu, X., Wu, Q., Chen, X., Cheng, S.H., Xu, S. (2024) Radix Rehmanniae Praeparata promoted zebrafish fin regeneration through aryl hydrocarbon receptor-dependent autophagy. Journal of ethnopharmacology. 331:118272
- Veroni, C., Olla, S., Brignone, M.S., Siguri, C., Formato, A., Marra, M., Manzoli, R., Macario, M.C., Ambrosini, E., Moro, E., Agresti, C. (2024) The Antioxidant Drug Edaravone Binds to the Aryl Hydrocarbon Receptor (AHR) and Promotes the Downstream Signaling Pathway Activation. Biomolecules. 14(4):
- Rude, C.I., Tidwell, L.G., Tilton, S.C., Waters, K.M., Anderson, K.A., Tanguay, R.L. (2023) Coupling Environmental Whole Mixture Toxicity Screening with Unbiased RNA-Seq Reveals Site-Specific Biological Responses in Zebrafish. Toxics. 11(3):
- Shankar, P., Garcia, G.R., LaDu, J.K., Sullivan, C.M., Dunham, C.L., Goodale, B.C., Waters, K.M., Stanisheuski, S., Maier, C.S., Thunga, P., Reif, D.M., Tanguay, R.L. (2022) The Ahr2-Dependent wfikkn1 Gene Influences Zebrafish Transcriptome, Proteome, and Behavior. Toxicological sciences : an official journal of the Society of Toxicology. 187(2):325-344
- Kim, Y.C., Lee, S.R., Jeon, H.J., Kim, K., Kim, M.J., Choi, S.D., Lee, S.E. (2020) Acute toxicities of fluorene, fluorene-1-carboxylic acid, and fluorene-9-carboxylic acid on zebrafish embryos (Danio rerio): Molecular mechanisms of developmental toxicities of fluorene-1-carboxylic acid. Chemosphere. 260:127622
- Ma, Y.N., Sun, L.H., Li, S.Y., Ni, Y.X., Cao, Z.Y., Chen, M.X., Mou, R.X. (2020) Modulation of steroid metabolism and xenobiotic biotransformation responses in zebrafish (Danio rerio) exposed to triadimefon. Environmental pollution (Barking, Essex : 1987). 262:114145
- Meng, Q., Yeung, K., Kwok, M.L., Chung, C.T., Hu, X.L., Chan, K.M. (2020) Toxic effects and transcriptome analyses of zebrafish (Danio rerio) larvae exposed to benzophenones. Environmental pollution (Barking, Essex : 1987). 265:114857
- Deng, S., Fu, A., Junaid, M., Wang, Y., Yin, Q., Fu, C., Liu, L., Su, D.S., Bian, W.P., Pei, D.S. (2019) Nitrogen-doped graphene quantum dots (N-GQDs) perturb redox-sensitive system via the selective inhibition of antioxidant enzyme activities in zebrafish. Biomaterials. 206:61-72
- Jin, H., Ji, C., Ren, F., Aniagu, S., Tong, J., Jiang, Y., Chen, T. (2019) AHR-mediated oxidative stress contributes to the cardiac developmental toxicity of trichloroethylene in zebrafish embryos. Journal of hazardous materials. 385:121521
- Lozza, L., Moura-Alves, P., Domaszewska, T., Lage Crespo, C., Streata, I., Kreuchwig, A., Puyskens, A., Bechtle, M., Klemm, M., Zedler, U., Silviu Ungureanu, B., Guhlich-Bornhof, U., Koehler, A.B., Stäber, M., Mollenkopf, H.J., Hurwitz, R., Furkert, J., Krause, G., Weiner, J., Jacinto, A., Mihai, I., Leite-de-Moraes, M., Siebenhaar, F., Maurer, M., Kaufmann, S.H.E. (2019) The Henna pigment Lawsone activates the Aryl Hydrocarbon Receptor and impacts skin homeostasis. Scientific Reports. 9:10878
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