Gene
st8sia1
- ID
- ZDB-GENE-051005-1
- Name
- ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
- Symbol
- st8sia1 Nomenclature History
- Previous Names
-
- zgc:158304
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity. Predicted to be involved in N-glycan processing; oligosaccharide metabolic process; and protein glycosylation. Predicted to act upstream of or within sphingolipid metabolic process. Predicted to be located in Golgi membrane. Is expressed in several structures, including corpuscles of Stannius; forebrain neural plate; kidney; nervous system; and unfertilized egg. Orthologous to human ST8SIA1 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Glycosyltransferase 29 (Sialyltransferase) | Glycosyl transferase family 29 | GT29-like superfamiliy | Sialyltransferase |
|---|---|---|---|---|---|---|
| UniProtKB:Q6KC13 | InterPro | 339 | ||||
| UniProtKB:A1A5W4 | InterPro | 145 |
1 - 2 of 2
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
st8sia1-201
(1)
|
Ensembl | 2,696 nt | ||
| mRNA |
st8sia1-202
(1)
|
Ensembl | 3,686 nt |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-204I4 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-117O14 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-193G4 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:158304 | ZFIN Curated Data |
1 - 4 of 4
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001327841 (1) | 3691 nt | ||
| Genomic | GenBank:CU137645 (1) | 292984 nt | ||
| Polypeptide | UniProtKB:Q6KC13 (1) | 339 aa |
- Chang, L.Y., Teppa, E., Noel, M., Gilormini, P.A., Decloquement, M., Lion, C., Biot, C., Mir, A.M., Cogez, V., Delannoy, P., Khoo, K.H., Petit, D., Guérardel, Y., Harduin-Lepers, A. (2019) Novel Zebrafish Mono-α2,8-sialyltransferase (ST8Sia VIII): An Evolutionary Perspective of α2,8-Sialylation. International Journal of Molecular Sciences. 20(3)
- Yamakawa, N., Vanbeselaere, J., Chang, L.Y., Yu, S.Y., Ducrocq, L., Harduin-Lepers, A., Kurata, J., Aoki-Kinoshita, K.F., Sato, C., Khoo, K.H., Kitajima, K., Guerardel, Y. (2018) Systems glycomics of adult zebrafish identifies organ-specific sialylation and glycosylation patterns. Nature communications. 9:4647
- Vanbeselaere, J., Chang, L.Y., Harduin-Lepers, A., Fabre, E., Yamakawa, N., Slomianny, C., Biot, C., Khoo, K.H., and Guerardel, Y. (2012) Mapping the expressed glycome and glycosyltransferases of zebrafish liver cells as a relevant model system for glycosylation studies. Journal of Proteome Research. 11(4):2164-2177
- Harduin-Lepers, A. (2010) Comprehensive Analysis of sialyltransferases in vertebrate genomes.. Glycobiology. 2010:2:29-61
- Chang, L.Y., Harduin-Lepers, A., Kitajima, K., Sato, C., Huang, C.J., Khoo, K.H., and Guérardel, Y. (2009) Developmental regulation of oligosialylation in zebrafish. Glycoconjugate journal. 26(3):247-261
- Chang, L.Y., Mir, A.M., Thisse, C., Guérardel, Y., Delannoy, P., Thisse, B., and Harduin-Lepers, A. (2009) Molecular cloning and characterization of the expression pattern of the zebrafish alpha2, 8-sialyltransferases (ST8Sia) in the developing nervous system. Glycoconjugate journal. 26(3):263-275
- Bentrop, J., Marx, M., Schattschneider, S., Rivera-Milla, E., and Bastmeyer, M. (2008) Molecular evolution and expression of zebrafish St8SiaIII, an alpha-2,8-sialyltransferase involved in myotome development. Developmental Dynamics : an official publication of the American Association of Anatomists. 237(3):808-818
- Harduin-Lepers, A., Petit, D., Mollicone, R., Delannoy, P., Petit, J.M., and Oriol, R. (2008) Evolutionary history of the alpha2,8-sialyltransferase (ST8Sia) gene family: tandem duplications in early deuterostomes explain most of the diversity found in the vertebrate ST8Sia genes. BMC Evolutionary Biology. 8:258
- Harduin-Lepers, A., Mollicone, R., Delannoy, P., and Oriol, R. (2005) The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach. Glycobiology. 15(8):805-817
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
1 - 10 of 10
Show