Gene

prkacbb

ID
ZDB-GENE-050904-4
Name
protein kinase, cAMP-dependent, catalytic, beta b
Symbol
prkacbb Nomenclature History
Previous Names
  • prkacb
  • si:ch1073-339l18.1
  • wu:fz54b03
  • zgc:110804 (1)
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to enable cAMP-dependent protein kinase activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within protein phosphorylation. Predicted to be part of cAMP-dependent protein kinase complex. Predicted to be active in cytosol and nucleus. Is expressed in brain; fin bud; otic vesicle; and retina. Orthologous to human PRKACB (protein kinase cAMP-activated catalytic subunit beta).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Emerson et al., 2018
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa25731Allele with one point mutationUnknownSplice SiteENU
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Sequence Targeting Reagents
No data available
Human Disease
Associated With prkacbb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Cardioacrofacial dysplasia 2 619143
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Associated With prkacbb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR000961 AGC-kinase, C-terminal
Family IPR044109 cAMP-dependent protein kinase catalytic subunit
1 - 5 of 6 Show all
Domain Details Per Protein
Protein Additional Resources Length AGC-kinase, C-terminal cAMP-dependent protein kinase catalytic subunit Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site
UniProtKB:A0A8M2BIA6 InterPro 354
UniProtKB:Q3ZB92 InterPro 351
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 2
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA prkacbb-201 (1) Ensembl 5,263 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-188C16ZFIN Curated Data
EncodesESTfz54b03
EncodescDNAMGC:110804ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanPRKACB1
Amino acid sequence comparison (3)
Conserved genome location (synteny) (1)
MousePrkacb3
Amino acid sequence comparison (2)
Citations
1 - 8 of 8
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