Gene
celsr1b
- ID
- ZDB-GENE-050823-4
- Name
- cadherin EGF LAG seven-pass G-type receptor 1b
- Symbol
- celsr1b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled receptor activity and calcium ion binding activity. Acts upstream of or within cell migration involved in gastrulation; heart development; and neural tube development. Predicted to be located in plasma membrane. Is expressed in several structures, including central nervous system; eye; notochord; pleuroperitoneal region; and spinal cord neural tube. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human CELSR1 (cadherin EGF LAG seven-pass G-type receptor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la023202Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la023203Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la028686Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la028687Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa426 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa10133 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa11458 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa12090 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa12454 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa13613 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Lymphatic malformation 9 | 619319 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cadherin conserved site | Cadherin-like | Cadherin-like superfamily | CELSR1-3-like, ninth cadherin domain | Concanavalin A-like lectin/glucanase domain superfamily | EGF-like calcium-binding domain | EGF-like domain | GAIN domain superfamily | GPCR, family 2, extracellular hormone receptor domain | GPCR family 2, extracellular hormone receptor domain superfamily | GPCR, family 2-like, 7TM | GPCR, family 2, secretin-like | GPS motif | Laminin G domain | Laminin-type EGF domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1QBS8 | InterPro | 3006 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
celsr1b-201
(1)
|
Ensembl | 9,761 nt | ||
| mRNA |
celsr1b-202
(1)
|
Ensembl | 14,090 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
- Joshi, B., Gaur, H., Hui, S.P., Patra, C. (2022) Celsr family genes are dynamically expressed in embryonic and juvenile zebrafish. Developmental Neurobiology. 82(2):192-213
- Li, C., Barton, C., Henke, K., Daane, J., Treaster, S., Caetano-Lopez, J., Tanguay, R.L., Harris, M. (2020) Celsr1a is essential for tissue homeostasis and onset of aging phenotypes in the zebrafish. eLIFE. 9:
- Menon, T., Borbora, A.S., Kumar, R., Nair, S. (2020) Dynamic optima in cell sizes during early development enable normal gastrulation in zebrafish embryos. Developmental Biology. 468(1-2):26-40
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Qiao, X., Liu, Y., Li, P., Chen, Z., Li, H., Yang, X., Finnell, R.H., Yang, Z., Zhang, T., Qiao, B., Zheng, Y., Wang, H. (2016) Genetic analysis of rare coding mutations in CELSR1-3 in Chinese Congenital Heart and Neural Tube Defects. Clinical science (London, England : 1979). 130(24):2329-2340
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Harty, B.L., Krishnan, A., Sanchez, N.E., Schiöth, H.B., Monk, K.R. (2015) Defining the gene repertoire and spatiotemporal expression profiles of adhesion G protein-coupled receptors in zebrafish. BMC Genomics. 16:62
- Rossi, A., Kontarakis, Z., Gerri, C., Nolte, H., Hölper, S., Krüger, M., Stainier, D.Y. (2015) Genetic compensation induced by deleterious mutations but not gene knockdowns. Nature. 524(7564):230-3
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Carreira-Barbosa, F., Kajita, M., Morel, V., Wada, H., Okamoto, H., Martinez Arias, A., Fujita, Y., Wilson, S.W., and Tada, M. (2009) Flamingo regulates epiboly and convergence/extension movements through cell cohesive and signalling functions during zebrafish gastrulation. Development (Cambridge, England). 136(3):383-392
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