Gene

cast

ID

ZDB-GENE-050810-2

Name

calpastatin

Symbol

cast Nomenclature History

Previous Names

sb:cb966 (1)
zgc:194249

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to have calcium-dependent cysteine-type endopeptidase inhibitor activity. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hypersensitivity disease (multiple); congenital myasthenic syndrome 1A; pemphigus; rheumatoid arthritis; and vasculitis. Is expressed in several structures, including digestive system; embryonic structure; epidermis; pectoral fin; and periderm. Orthologous to human CAST (calpastatin).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

11 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

cb966 (7 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cast Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
PLACK syndrome	Alliance	Peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads	616295

Associated With cast Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR026998	Calpastatin
Repeat	IPR001259	Proteinase inhibitor I27, calpastatin

Domain Details Per Protein

Protein	Length	Calpastatin	Proteinase inhibitor I27, calpastatin
UniProtKB:A0A8M2B7Y5 InterPro	802
UniProtKB:A0A8M9PQJ2 InterPro	734
UniProtKB:A0A8M9PIC6 InterPro	834
UniProtKB:A0A8M9P3E0 InterPro	697
UniProtKB:A0A8M2B800 InterPro	724
UniProtKB:A0A8M6YUH4 InterPro	835
UniProtKB:A0A8M2B7Z9 InterPro	792
UniProtKB:A0A8M9PTZ9 InterPro	720
UniProtKB:A0A8M9P3D7 InterPro	730
UniProtKB:A0A8M2B7Y6 InterPro	734
UniProtKB:A0A8M9PQJ5 InterPro	707
UniProtKB:A0A8M9PCQ8 InterPro	841
UniProtKB:A0A8M6Z304 InterPro	831
UniProtKB:A0A8M3ALB2 InterPro	845
UniProtKB:A0A8M9PTY8 InterPro	818
UniProtKB:A0A8M6YWX8 InterPro	696
UniProtKB:A0A8M1NI55 InterPro	818
UniProtKB:A0A8M9P3D4 InterPro	802
UniProtKB:A0A8M2B7Y0 InterPro	811
UniProtKB:A0A8M2B7Z1 InterPro	757
UniProtKB:F1QZT8 InterPro	839
UniProtKB:A0A8M9PTZ2 InterPro	763
UniProtKB:A0A8M2B7Y7 InterPro	824
UniProtKB:A0A8M2B873 InterPro	733
UniProtKB:A0A8M9PCR3 InterPro	730
UniProtKB:A0A8M9PQI9 InterPro	814
UniProtKB:A0A0R4IPE6 InterPro	835
UniProtKB:A0A8M2B7Z6 InterPro	700
UniProtKB:A0A8M9PID2 InterPro	728
UniProtKB:A0A8M2B865 InterPro	845
UniProtKB:A0A8M9PIC9 InterPro	767

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	cast-201 (1) Ensembl	Ensembl	2527 nt	Select Tool ZFIN BLAST
mRNA	cast-202 (1) Ensembl	Havana	710 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	cast-203 (1) Ensembl	Havana	3766 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	cast-204 (1) Ensembl	Havana	1062 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	cast-205 (1) Ensembl	Havana	895 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	cast-207 (1) Ensembl	Havana	729 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	cast-208 (1) Ensembl	Havana	645 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	cast-209 (1) Ensembl	Havana	977 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	cast-211 (1) Ensembl	Havana	462 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	cast-212 (1) Ensembl	Havana	762 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	cast-213 (1) Ensembl	Havana	843 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	cast-214 (1) Ensembl	Havana	398 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	cast-215 (1) Ensembl	Havana	576 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	cast-216 (1) Ensembl	Havana	747 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	cast-217 (1) Ensembl	Ensembl	2515 nt	Select Tool ZFIN BLAST
mRNA	cast-218 (1) Ensembl	Ensembl	2443 nt	Select Tool ZFIN BLAST
mRNA	cast-219 (1) Ensembl	Ensembl	2734 nt	Select Tool ZFIN BLAST
ncRNA	cast-014 (1) Ensembl	Havana	328 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	cast-015 (1) Ensembl	Havana	467 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations