ZFIN is now using GRCz12tu for Genomic Data
Gene
wfs1b
- ID
- ZDB-GENE-050809-19
- Name
- Wolfram syndrome 1b (wolframin)
- Symbol
- wfs1b Nomenclature History
- Previous Names
-
- im:7150991
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to be involved in calcium ion homeostasis and endoplasmic reticulum unfolded protein response. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including central nervous system; eye; otic epithelium; otic vesicle; and pleuroperitoneal region. Used to study Wolfram syndrome. Human ortholog(s) of this gene implicated in several diseases, including Wolfram syndrome (multiple); auditory system disease (multiple); cataract 41; diabetes mellitus (multiple); and optic atrophy (multiple). Orthologous to human WFS1 (wolframin ER transmembrane glycoprotein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7150991 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 15 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nonsyndromic deafness 6 | Alliance | Deafness, autosomal dominant 6/14/38 | 600965 |
| autosomal dominant Wolfram syndrome | Alliance | Wolfram-like syndrome, autosomal dominant | 614296 |
| cataract 41 | Alliance | ?Cataract 41 | 116400 |
| type 2 diabetes mellitus | Alliance | {Diabetes mellitus, noninsulin-dependent, association with} | 125853 |
| Wolfram syndrome 1 | Alliance | Wolfram syndrome 1 | 222300 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| Wolfram syndrome | wfs1bsa16422/sa16422 (AB) | standard conditions | Cairns et al., 2021 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR045400 | Wolframin, cysteine-rich domain |
| Domain | IPR045460 | Wolframin, EF-hand domain |
| Domain | IPR045461 | Wolframin, OB-fold domain |
| Family | IPR026208 | Wolframin |
| Family | IPR026209 | Wolframin family |
| Homologous_superfamily | IPR011990 | Tetratricopeptide-like helical domain superfamily |
| Repeat | IPR045458 | Wolframin, Sel1-like repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | Tetratricopeptide-like helical domain superfamily | Wolframin | Wolframin, cysteine-rich domain | Wolframin, EF-hand domain | Wolframin family | Wolframin, OB-fold domain | Wolframin, Sel1-like repeat |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:E7F921 | InterPro | 895 | |||||||
| UniProtKB:A0A8M9QKW2 | InterPro | 714 | |||||||
| UniProtKB:A0AC58H7C0 | InterPro | 895 | |||||||
| UniProtKB:A0ACD6B6V0 | InterPro | 895 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers