ZFIN is now using GRCz12tu for Genomic Data
Gene
mrpl2
- ID
- ZDB-GENE-050809-12
- Name
- mitochondrial ribosomal protein L2
- Symbol
- mrpl2 Nomenclature History
- Previous Names
-
- im:6908224
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be located in mitochondrial inner membrane. Predicted to be part of mitochondrial large ribosomal subunit. Is expressed in visceral fat. Orthologous to human MRPL2 (mitochondrial ribosomal protein L2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6908224 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR022666 | Large ribosomal subunit protein uL2, RNA-binding domain |
| Domain | IPR022669 | Large ribosomal subunit protein uL2, C-terminal |
| Family | IPR002171 | Large ribosomal subunit protein uL2 |
| Homologous_superfamily | IPR008991 | Translation protein SH3-like domain superfamily |
| Homologous_superfamily | IPR012340 | Nucleic acid-binding, OB-fold |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Large ribosomal subunit protein uL2 | Large ribosomal subunit protein uL2, C-terminal | Large ribosomal subunit protein uL2, domain 2 | Large ribosomal subunit protein uL2, RNA-binding domain | Nucleic acid-binding, OB-fold | Translation protein SH3-like domain superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1P304 | InterPro | 294 | ||||||
| UniProtKB:A0AB32T0N1 | InterPro | 290 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Encodes | EST | IMAGE:6908224 | Thisse et al., 2004 |
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- Genome Browsers
| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001327785 (1) | 1609 nt | ||
| Genomic | GenBank:JBMGRA010000013 (1) | |||
| Polypeptide | UniProtKB:A0A8M1P304 (1) | 294 aa |
- Xu, Y., Zhang, S., Bao, Y., Luan, J., Fu, Z., Sun, M., Zhao, X., Feng, X. (2024) Melatonin protects zebrafish pancreatic development and physiological rhythms from sodium propionate-induced disturbances via the hypothalamic-pituitary-thyroid axis. Journal of the science of food and agriculture. 104(12):7454-7463
- Posner, M., McDonald, M.S., Murray, K.L., Kiss, A.J. (2019) Why does the zebrafish cloche mutant develop lens cataract?. PLoS One. 14:e0211399
- Peng, X., Shang, G., Wang, W., Chen, X., Lou, Q., Zhai, G., Li, D., Du, Z., Ye, Y., Jin, X., He, J., Zhang, Y., Yin, Z. (2017) Fatty Acid Oxidation in Zebrafish Adipose Tissue Is Promoted by 1α,25(OH)2D3.. Cell Reports. 19:1444-1455
- Reischauer, S., Stone, O.A., Villasenor, A., Chi, N., Jin, S.W., Martin, M., Lee, M.T., Fukuda, N., Marass, M., Witty, A., Fiddes, I., Kuo, T., Chung, W.S., Salek, S., Lerrigo, R., Alsiö, J., Luo, S., Tworus, D., Augustine, S.M., Mucenieks, S., Nystedt, B., Giraldez, A.J., Schroth, G.P., Andersson, O., Stainier, D.Y. (2016) Cloche is a bHLH-PAS transcription factor that drives haemato-vascular specification. Nature. 535:294-8
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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