Gene

gfi1aa

ID

ZDB-GENE-050522-534

Name

growth factor independent 1A transcription repressor a

Symbol

gfi1aa Nomenclature History

Previous Names

gfi1.1
gfi1a
zgc:113277 (1)

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within hemangioblast cell differentiation and primitive erythrocyte differentiation. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. Is expressed in several structures, including artery; hematopoietic cell; inner ear; lateral line system; and mesoderm. Used to study myelodysplastic syndrome. Human ortholog(s) of this gene implicated in acute myeloid leukemia and severe congenital neutropenia 2. Orthologous to human GFI1 (growth factor independent 1 transcriptional repressor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

25 figures from 12 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7158523 (10 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 23 figures from 7 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gfi1aa Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
severe congenital neutropenia 2	Alliance	Neutropenia, severe congenital 2, autosomal dominant	613107
		?Neutropenia, nonimmune chronic idiopathic, of adults	607847

Associated With gfi1aa Via Experimental Models

Human Disease	Fish	Conditions	Citations
myelodysplastic syndrome	gfi1aa^szy5/szy5; i114Tg/i114Tg	standard conditions	Wu et al., 2021

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR013087	Zinc finger C2H2-type
Family	IPR050331	Zinc finger
Homologous_superfamily	IPR036236	Zinc finger C2H2 superfamily

Domain Details Per Protein

Protein	Additional Resources	Length	Zinc finger	Zinc finger C2H2 superfamily	Zinc finger C2H2-type
UniProtKB:Q501T1	InterPro	385
UniProtKB:A0AB32U1L7	InterPro	385

Transcripts

Genome Browsers

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	gfi1aa-201 (1) Ensembl	Ensembl		1,464 nt	Select Tool ZFIN BLAST
mRNA	gfi1aa-202 (1) Ensembl	Ensembl		1,607 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations