Gene
c9
- ID
- ZDB-GENE-050522-442
- Name
- complement component 9
- Symbol
- c9 Nomenclature History
- Previous Names
-
- wu:fb60b05
- wu:fd50e04
- zgc:112272
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Involved in cellular response to estrogen stimulus. Predicted to localize to membrane attack complex. Human ortholog(s) of this gene implicated in age related macular degeneration 15 and complement component 9 deficiency. Is expressed in liver and yolk syncytial layer. Orthologous to human C9 (complement C9).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 21 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:112272 (5 images)
- IMAGE:7140385 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| age related macular degeneration 15 | Alliance | {Macular degeneration, age-related, 15, susceptibility to} | 615591 |
| complement component 9 deficiency | Alliance | C9 deficiency | 613825 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020863 | Membrane attack complex component/perforin domain, conserved site |
| Domain | IPR020864 | Membrane attack complex component/perforin (MACPF) domain |
| Family | IPR001862 | Membrane attack complex component/perforin/complement C9 |
| Homologous_superfamily | IPR036055 | LDL receptor-like superfamily |
| Homologous_superfamily | IPR036383 | Thrombospondin type-1 (TSP1) repeat superfamily |
| Repeat | IPR000884 | Thrombospondin type-1 (TSP1) repeat |
| Repeat | IPR002172 | Low-density lipoprotein (LDL) receptor class A repeat |
Domain Details Per Protein
| Protein | Length | LDL receptor-like superfamily | Low-density lipoprotein (LDL) receptor class A repeat | Membrane attack complex component/perforin/complement C9 | Membrane attack complex component/perforin domain, conserved site | Membrane attack complex component/perforin (MACPF) domain | Thrombospondin type-1 (TSP1) repeat | Thrombospondin type-1 (TSP1) repeat superfamily |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:B8A565
|
673 |
Interactions and Pathways
No data available
Plasmids
No data available