Gene

gtpbp3

ID
ZDB-GENE-050522-335
Name
GTP binding protein 3, mitochondrial
Symbol
gtpbp3 Nomenclature History
Previous Names
  • zgc:112394 (1)
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to have GTP binding activity and GTPase activity. Involved in embryonic organ development. Localizes to mitochondrion. Is expressed in several structures, including eye; heart; integument; liver; and pleuroperitoneal region. Used to study mitochondrial metabolism disease. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 23. Orthologous to human GTPBP3 (GTP binding protein 3, mitochondrial).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
10 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gtpbp3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
combined oxidative phosphorylation deficiency 23 Alliance Combined oxidative phosphorylation deficiency 23 616198
Associated With gtpbp3 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR005225 Small GTP-binding protein domain
Domain IPR006073 GTP binding domain
Domain IPR018948 GTP-binding protein TrmE, N-terminal
Domain IPR025867 MnmE, helical domain
Domain IPR031168 TrmE-type guanine nucleotide-binding domain
Family IPR004520 tRNA modification GTPase MnmE
Homologous_superfamily IPR027266 GTP-binding protein TrmE/Aminomethyltransferase GcvT, domain 1
Homologous_superfamily IPR027368 tRNA modification GTPase MnmE domain 2
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Domain Details Per Protein
Protein Length GTP binding domain GTP-binding protein TrmE/Aminomethyltransferase GcvT, domain 1 GTP-binding protein TrmE, N-terminal MnmE, helical domain P-loop containing nucleoside triphosphate hydrolase Small GTP-binding protein domain TrmE-type guanine nucleotide-binding domain tRNA modification GTPase MnmE tRNA modification GTPase MnmE domain 2
UniProtKB:A0A2R8QCU4 489
UniProtKB:Q501Z5 500
UniProtKB:A0A2R8RKH9 466
UniProtKB:A0A077CZD0 471
UniProtKB:A0A077D3Q6 447
UniProtKB:F1Q694 500
UniProtKB:A0A0R4IP96 239
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations