Gene

ints11

ID

ZDB-GENE-050522-13

Name

integrator complex subunit 11

Symbol

ints11 Nomenclature History

Previous Names

ints11 (1)
cpsf3l (1)
zgc:110671

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to have hydrolase activity. Involved in regulation of RNA splicing. Predicted to localize to nucleus. Orthologous to human INTS11 (integrator complex subunit 11).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Tao et al., 2009
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ints11 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
neurodevelopmental disorder with motor and language delay, ocular defects, and brain abnormalities	Alliance	Neurodevelopmental disorder with motor and language delay, ocular defects, and brain abnormalities	620428

Associated With ints11 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001279	Metallo-beta-lactamase
Domain	IPR011108	Zn-dependent metallo-hydrolase, RNA specificity domain
Domain	IPR022712	Beta-Casp domain
Domain	IPR041897	Integrator complex subunit 11, MBL-fold
Domain	IPR048662	Integrator complex subunit 11, C-terminal domain
Homologous_superfamily	IPR036866	Ribonuclease Z/Hydroxyacylglutathione hydrolase-like

Domain Details Per Protein

Protein	Length	Beta-Casp domain	Integrator complex subunit 11, C-terminal domain	Integrator complex subunit 11, MBL-fold	Metallo-beta-lactamase	Ribonuclease Z/Hydroxyacylglutathione hydrolase-like	Zn-dependent metallo-hydrolase, RNA specificity domain
UniProtKB:F1QEY5 InterPro	598
UniProtKB:Q503E1 InterPro	598

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ints11-202 (1) Ensembl	Havana	1740 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	ints11-203 (1) Ensembl	Havana	937 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations