Gene
abcd1
- ID
- ZDB-GENE-050517-27
- Name
- ATP-binding cassette, sub-family D (ALD), member 1
- Symbol
- abcd1 Nomenclature History
- Previous Names
-
- zgc:172102 (1)
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable ATP binding activity; ATPase-coupled transmembrane transporter activity; and long-chain fatty acid transporter activity. Involved in several processes, including oligodendrocyte development; positive regulation of myelination; and swimming behavior. Acts upstream of or within cholesterol transport. Predicted to be located in peroxisome. Predicted to be active in peroxisomal membrane. Is expressed in central nervous system; floor plate; gut; interrenal gland; and pronephros. Used to study adrenoleukodystrophy. Human ortholog(s) of this gene implicated in adrenoleukodystrophy. Orthologous to human ABCD1 (ATP binding cassette subfamily D member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Strachan et al., 2017
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| adrenoleukodystrophy | Alliance | Adrenoleukodystrophy | 300100 |
| adrenoleukodystrophy | Alliance | Adrenomyeloneuropathy, adult | 300100 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| adrenoleukodystrophy | abcd1zc92/zc92 | standard conditions | Raas et al., 2021 |
| adrenoleukodystrophy | abcd1sa509/sa509 | standard conditions | (2) |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017871 | ABC transporter-like, conserved site |
| Domain | IPR003439 | ABC transporter-like, ATP-binding domain |
| Domain | IPR003593 | AAA+ ATPase domain |
| Domain | IPR011527 | ABC transporter type 1, transmembrane domain |
| Family | IPR031237 | ATP-binding cassette sub-family D member 1 |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036640 | ABC transporter type 1, transmembrane domain superfamily |
Domain Details Per Protein
| Protein | Length | AAA+ ATPase domain | ABC transporter-like, ATP-binding domain | ABC transporter-like, conserved site | ABC transporter type 1, transmembrane domain | ABC transporter type 1, transmembrane domain superfamily | ATP-binding cassette sub-family D member 1 | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A9JRC4
|
640 | |||||||
|
UniProtKB:F1RBC8
|
766 |
Interactions and Pathways
No data available
Plasmids
No data available