Gene
ncapd2
- ID
- ZDB-GENE-050506-59
- Name
- non-SMC condensin I complex, subunit D2
- Symbol
- ncapd2 Nomenclature History
- Previous Names
-
- cap-d2 (1)
- im:6902697
- si:dkey-175g20.1
- wu:fc13f08
- wu:fx06e10
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable histone binding activity. Acts upstream of or within mitotic sister chromatid segregation. Predicted to be located in chromosome; cytoplasm; and nucleus. Predicted to be part of condensin complex. Predicted to be active in condensed chromosome, centromeric region. Is expressed in nervous system; optic cup; pectoral fin; pharyngeal arch 3-7 skeleton; and proliferative region. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 21. Orthologous to human NCAPD2 (non-SMC condensin I complex subunit D2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6902697 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Seipold et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary autosomal recessive microcephaly 21 | Alliance | Microcephaly 21, primary, autosomal recessive | 617983 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR024324 | Condensin complex subunit 1, N-terminal |
| Domain | IPR032682 | Condensin complex subunit 1, C-terminal |
| Family | IPR007673 | Condensin subunit 1 |
| Family | IPR026971 | Condensin subunit 1/Condensin-2 complex subunit D3 |
| Homologous_superfamily | IPR011989 | Armadillo-like helical |
| Homologous_superfamily | IPR016024 | Armadillo-type fold |
Domain Details Per Protein
| Protein | Additional Resources | Length | Armadillo-like helical | Armadillo-type fold | Condensin complex subunit 1, C-terminal | Condensin complex subunit 1, N-terminal | Condensin subunit 1 | Condensin subunit 1/Condensin-2 complex subunit D3 |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1NUS6 | InterPro | 1380 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ncapd2-201
(1)
|
Ensembl | 4,412 nt | ||
| mRNA |
ncapd2-203
(1)
|
Ensembl | 5,497 nt | ||
| ncRNA |
ncapd2-002
(1)
|
Ensembl | 746 nt |
Interactions and Pathways
No data available
Plasmids
No data available