Gene

ncapd2

ID

ZDB-GENE-050506-59

Name

non-SMC condensin I complex, subunit D2

Symbol

ncapd2 Nomenclature History

Previous Names

cap-d2 (1)
im:6902697
si:dkey-175g20.1
wu:fc13f08
wu:fx06e10

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to have chromatin binding activity and histone binding activity. Involved in mitotic sister chromatid segregation. Predicted to localize to condensed chromosome, centromeric region and nuclear condensin complex. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly. Is expressed in nervous system; optic cup; pectoral fin; pharyngeal arch 3-7 skeleton; and proliferative region. Orthologous to human NCAPD2 (non-SMC condensin I complex subunit D2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

IMAGE:6902697 (10 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Seipold et al., 2009
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ncapd2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		?Microcephaly 21, primary, autosomal recessive	617983

Associated With ncapd2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR024324	Condensin complex subunit 1, N-terminal
Domain	IPR032682	Condensin complex subunit 1, C-terminal
Family	IPR007673	Condensin subunit 1
Family	IPR026971	Condensin subunit 1/Condensin-2 complex subunit D3
Homologous_superfamily	IPR011989	Armadillo-like helical
Homologous_superfamily	IPR016024	Armadillo-type fold

Domain Details Per Protein

Protein	Length	Armadillo-like helical	Armadillo-type fold	Condensin complex subunit 1, C-terminal	Condensin complex subunit 1, N-terminal	Condensin subunit 1	Condensin subunit 1/Condensin-2 complex subunit D3
UniProtKB:Q568Q3 InterPro	531
UniProtKB:A7MCQ4 InterPro	454
UniProtKB:Q7SXS6 InterPro	979
UniProtKB:A0A0R4IRW7 InterPro	1404
UniProtKB:A2RV05 InterPro	1414
UniProtKB:Q6IQB9 InterPro	508
UniProtKB:B0V123 InterPro	1380

Transcripts

Genome Browsers

Type	Name	Length (nt)	Analysis
mRNA	ncapd2-201 (1) Ensembl	4412 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	ncapd2-002 (1) Ensembl	746 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations