Gene

wt1b

ID

ZDB-GENE-050420-319

Name

WT1 transcription factor b

Symbol

wt1b Nomenclature History

Previous Names

si:ch211-160j6.3 (1)
zgc:152697 (1)

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in animal organ development and glial cell development. Predicted to localize to nuclear chromatin. Is expressed in several structures, including eye; heart; intermediate mesoderm; pleuroperitoneal region; and podocyte. Human ortholog(s) of this gene implicated in several diseases, including Denys-Drash syndrome; Frasier syndrome; malignant mesothelioma; nephroblastoma; and nephrotic syndrome type 4. Orthologous to human WT1 (WT1 transcription factor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

40 figures from 19 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 8 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With wt1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Denys-Drash syndrome	194080
		Frasier syndrome	136680
		Meacham syndrome	608978
		Mesothelioma, somatic	156240
		Nephrotic syndrome, type 4	256370
		Wilms tumor, type 1	194070