Gene

tnni2b.1

ID

ZDB-GENE-050417-49

Name

troponin I type 2b (skeletal, fast), tandem duplicate 1

Symbol

tnni2b.1 Nomenclature History

Previous Names

tropI-2a (1)
zgc:110715

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to be involved in cardiac muscle contraction and skeletal muscle contraction. Predicted to localize to troponin complex. Human ortholog(s) of this gene implicated in distal arthrogryposis type 2B1 and intrinsic cardiomyopathy (multiple). Orthologous to several human genes including TNNI2 (troponin I2, fast skeletal type).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Peng et al., 2021

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tnni2b.1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
distal arthrogryposis type 2B1	Alliance	Arthrogryposis, distal, type 2B1	601680

Associated With tnni2b.1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR001978	Troponin
Homologous_superfamily	IPR038077	Troponin domain superfamily

Domain Details Per Protein

Protein	Length	Troponin	Troponin domain superfamily
UniProtKB:F1QCC0 InterPro	176
UniProtKB:Q567W1 InterPro	176

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	tnni2b.1-201 (1) Ensembl	Havana	999 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tnni2b.1-203 (1) Ensembl	Havana	990 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tnni2b.1-204 (1) Ensembl	Havana	506 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	tnni2b.1-003 (1) Ensembl	Havana	1101 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	tnni2b.1-005 (1) Ensembl	Havana	677 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl
Note: tnni2b.1 and tnni2b.2 form a cluster on chromosome 7 and are likely the result of a tandem duplication. The location of the cluster in zebrafish as well as the amino acid identity of both genes support orthology to human TNNI2 and mouse Tnni2.

Citations