Gene

nfu1

ID

ZDB-GENE-050417-365

Name

NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae)

Symbol

nfu1 Nomenclature History

Previous Names

HIRA interacting protein 5
hirip5 (1)
zgc:109711

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to have 4 iron, 4 sulfur cluster binding activity and iron ion binding activity. Predicted to be involved in iron-sulfur cluster assembly and protein maturation by iron-sulfur cluster transfer. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 1. Orthologous to human NFU1 (NFU1 iron-sulfur cluster scaffold).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:109711 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nfu1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
multiple mitochondrial dysfunctions syndrome 1	Alliance	Multiple mitochondrial dysfunctions syndrome 1	605711

Associated With nfu1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001075	NIF system FeS cluster assembly, NifU, C-terminal
Domain	IPR014824	Scaffold protein Nfu/NifU, N-terminal
Family	IPR035433	NFU1-like
Homologous_superfamily	IPR034904	Fe-S cluster assembly domain superfamily
Homologous_superfamily	IPR036498	Scaffold protein Nfu/NifU, N-terminal domain superfamily

Domain Details Per Protein

Protein	Length	Fe-S cluster assembly domain superfamily	NFU1-like	NIF system FeS cluster assembly, NifU, C-terminal	Scaffold protein Nfu/NifU, N-terminal	Scaffold protein Nfu/NifU, N-terminal domain superfamily
UniProtKB:B0S8L0 InterPro	243

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	nfu1-201 (1) Ensembl	Havana	1651 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	nfu1-002 (1) Ensembl	Havana	812 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations