Gene

slc24a4a

ID
ZDB-GENE-050417-291
Name
solute carrier family 24 member 4a
Symbol
slc24a4a Nomenclature History
Previous Names
  • zgc:112072
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to have calcium channel activity and calcium, potassium:sodium antiporter activity. Predicted to be involved in calcium ion transmembrane transport and cellular calcium ion homeostasis. Predicted to localize to integral component of plasma membrane. Is expressed in brain; neural crest; and retina. Human ortholog(s) of this gene implicated in amelogenesis imperfecta hypomaturation type 2A5. Orthologous to human SLC24A4 (solute carrier family 24 member 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
7 figures from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With slc24a4a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
amelogenesis imperfecta hypomaturation type 2A5 Alliance Amelogenesis imperfecta, type IIA5 615887
[Skin/hair/eye pigmentation 6, blond/brown hair] 210750
[Skin/hair/eye pigmentation 6, blue/green eyes] 210750
Associated With slc24a4a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR004837 Sodium/calcium exchanger membrane region
Family IPR004481 Sodium/potassium/calcium exchanger
Homologous_superfamily IPR044880 NCX, central ion-binding domain superfamily
Domain Details Per Protein
Protein Length NCX, central ion-binding domain superfamily Sodium/calcium exchanger membrane region Sodium/potassium/calcium exchanger
UniProtKB:A0A8M3AJ61 620
UniProtKB:A0A8M2B5T1 621
UniProtKB:Q567G1 569
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations