ZFIN is now using GRCz12tu for Genomic Data
Gene
rhbdl3
- ID
- ZDB-GENE-050417-2
- Name
- rhomboid, veinlet-like 3 (Drosophila)
- Symbol
- rhbdl3 Nomenclature History
- Previous Names
-
- si:dkey-10p5.8 (1)
- zgc:113283
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable serine-type endopeptidase activity. Predicted to be located in membrane. Is expressed in several structures, including basal plate midbrain region; hatching gland; midbrain neural keel; nervous system; and presumptive diencephalon. Orthologous to human RHBDL3 (rhomboid like 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7159784 (20 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa15612 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | EF-Hand 1, calcium-binding site | EF-hand domain | EF-hand domain pair | Peptidase S54, rhomboid domain | Peptidase S54, rhomboid, metazoan | Rhomboid-like superfamily | Rhomboid-related Intramembrane Serine Proteases |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q2A943 | InterPro | 407 | |||||||
| UniProtKB:A0A8M2BDK9 | InterPro | 388 | |||||||
| UniProtKB:Q566N3 | InterPro | 306 | |||||||
| UniProtKB:A0A8M3BAC5 | InterPro | 399 | |||||||
| UniProtKB:A0A8M9Q644 | InterPro | 297 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
rhbdl3-201
(1)
|
Ensembl | 1,549 nt | ||
| mRNA |
rhbdl3-202
(1)
|
Ensembl | 1,834 nt | ||
| mRNA |
rhbdl3-203
(1)
|
Ensembl | 2,931 nt | ||
| mRNA |
rhbdl3-204
(1)
|
Ensembl | 1,858 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-10P5 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-260O3 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7159784 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:113283 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191436 | ZFIN Curated Data |
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| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001017556 (1) | 1579 nt | ||
| Genomic | GenBank:AL954746 (2) | 231840 nt | ||
| Polypeptide | UniProtKB:Q2A943 (1) | 407 aa |
- Qin, H., Yu, S., Han, R., He, J. (2025) Age-dependent glial heterogeneity and traumatic injury responses in a vertebrate brain structure. Cell Reports. 44:115508115508
- Klangnurak, W., Tokumoto, T. (2017) Fine selection of up-regulated genes during ovulation by in vivo induction of oocyte maturation and ovulation in zebrafish.. Zoological letters. 3:2
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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