Gene

glb1

ID
ZDB-GENE-050410-9
Name
galactosidase, beta 1
Symbol
glb1 Nomenclature History
Previous Names
  • zgc:110823
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Exhibits beta-galactosidase activity. Predicted to be involved in carbohydrate metabolic process. Predicted to localize to vacuole. Human ortholog(s) of this gene implicated in GM1 gangliosidosis (multiple) and mucopolysaccharidosis IV (multiple). Orthologous to human GLB1 (galactosidase beta 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With glb1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
GM1 gangliosidosis type 1 Alliance GM1-gangliosidosis, type I 230500
GM1 gangliosidosis type 2 Alliance GM1-gangliosidosis, type II 230600
GM1 gangliosidosis type 3 Alliance GM1-gangliosidosis, type III 230650
mucopolysaccharidosis type IVB Alliance Mucopolysaccharidosis type IVB (Morquio) 253010
Associated With glb1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019801 Glycoside hydrolase, family 35, conserved site
Domain IPR025300 Beta-galactosidase jelly roll domain
Domain IPR031330 Glycoside hydrolase 35, catalytic domain
Family IPR001944 Glycoside hydrolase, family 35
Family IPR026283 Beta-galactosidase 1-like
Homologous_superfamily IPR008979 Galactose-binding-like domain superfamily
Homologous_superfamily IPR017853 Glycoside hydrolase superfamily
Domain Details Per Protein
Protein Length Beta-galactosidase 1-like Beta-galactosidase jelly roll domain Galactose-binding-like domain superfamily Glycoside hydrolase 35, catalytic domain Glycoside hydrolase, family 35 Glycoside hydrolase, family 35, conserved site Glycoside hydrolase superfamily
UniProtKB:A2BG54 676
UniProtKB:A0A3T1CVI5 651
UniProtKB:Q56A50 651
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations