Gene

nr1h3

ID
ZDB-GENE-050410-7
Name
nuclear receptor subfamily 1, group H, member 3
Symbol
nr1h3 Nomenclature History
Previous Names
  • im:7141239
  • lxr (1)
  • LXRalpha (1)
  • wu:fd59b01
  • zgc:113339
  • zgc:158542
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Exhibits nuclear receptor activity. Involved in several processes, including embryonic viscerocranium morphogenesis; lipid homeostasis; and regulation of intestinal lipid absorption. Predicted to localize to RNA polymerase II transcription factor complex. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Is expressed in several structures, including brain; digestive system; eye; heart; and pleuroperitoneal region. Orthologous to several human genes including NR1H3 (nuclear receptor subfamily 1 group H member 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
14 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nr1h3 Human Ortholog
No data available
Associated With nr1h3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000536 Nuclear hormone receptor, ligand-binding domain
Domain IPR001628 Zinc finger, nuclear hormone receptor-type
Family IPR001723 Nuclear hormone receptor
Family IPR023257 Liver X receptor
Homologous_superfamily IPR013088 Zinc finger, NHR/GATA-type
Homologous_superfamily IPR035500 Nuclear hormone receptor-like domain superfamily
Domain Details Per Protein
Protein Length Liver X receptor Nuclear hormone receptor Nuclear hormone receptor, ligand-binding domain Nuclear hormone receptor-like domain superfamily Zinc finger, NHR/GATA-type Zinc finger, nuclear hormone receptor-type
UniProtKB:Q56A56 412
UniProtKB:A1L1Z8 323
UniProtKB:A0A0R4IVP0 441
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations