Gene

eya4

ID
ZDB-GENE-050327-93
Name
EYA transcriptional coactivator and phosphatase 4
Symbol
eya4 Nomenclature History
Previous Names
  • im:7221408
  • zgc:113079
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Is predicted to enable protein tyrosine phosphatase activity. Involved in several processes, including histone dephosphorylation; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; and positive regulation of DNA repair. Acts upstream of or within embryonic organ development; posterior lateral line neuromast hair cell differentiation; and startle response. Predicted to be located in cytoplasm. Is expressed in several structures, including otic epithelium; otic vesicle; pericardial region; pharyngeal arch; and sensory system. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 10; congestive heart failure; dilated cardiomyopathy; dilated cardiomyopathy 1J; and sensorineural hearing loss. Orthologous to human EYA4 (EYA transcriptional coactivator and phosphatase 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from Wang et al., 2008
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With eya4 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 10 Alliance Deafness, autosomal dominant 10 601316
dilated cardiomyopathy 1J Alliance ?Cardiomyopathy, dilated, 1J 605362
Associated With eya4 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR006545 EYA domain
Domain IPR042577 EYA domain, metazoan
Family IPR028472 Eyes absent family
Family IPR028478 Eyes absent homologue 4
Homologous_superfamily IPR038102 EYA domain superfamily
Domain Details Per Protein
Protein Length EYA domain EYA domain, metazoan EYA domain superfamily Eyes absent family Eyes absent homologue 4
UniProtKB:E9QGZ3 636
UniProtKB:A0A0R4IA41 638
UniProtKB:F1Q5R9 613
UniProtKB:Q58EJ5 256
UniProtKB:E9QGF5 636
UniProtKB:E7FA98 261
UniProtKB:E9QIR1 613
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations