ZFIN is now using GRCz12tu for Genomic Data
Gene
mfge8a
- ID
- ZDB-GENE-050327-9
- Name
- milk fat globule EGF and factor V/VIII domain containing a
- Symbol
- mfge8a Nomenclature History
- Previous Names
-
- mfge8l
- im:6895406
- zgc:110846
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable phosphatidylserine binding activity. Predicted to be active in extracellular space. Is expressed in central nervous system; forebrain; hindbrain; optic tectum; and ventricular zone. Human ortholog(s) of this gene implicated in temporal arteritis. Orthologous to human MFGE8 (milk fat globule EGF and factor V/VIII domain containing).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6895406 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Luo et al., 2023
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
| Domain | IPR000421 | Coagulation factor 5/8, C-terminal domain |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Family | IPR050633 | Neuropilin/Multicopper Oxidase/Coagulation Factor |
| Homologous_superfamily | IPR008979 | Galactose-binding-like domain superfamily |
| PTM | IPR000152 | EGF-type aspartate/asparagine hydroxylation site |
Domain Details Per Protein
| Protein | Additional Resources | Length | Coagulation factor 5/8, C-terminal domain | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Galactose-binding-like domain superfamily | Neuropilin/Multicopper Oxidase/Coagulation Factor |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A4QP32 | InterPro | 478 | |||||||
| UniProtKB:A0AC58FZ50 | InterPro | 356 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mfge8a-201
(1)
|
Ensembl | 2,589 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers