Gene

ikbkg

ID
ZDB-GENE-050327-68
Name
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
Symbol
ikbkg Nomenclature History
Previous Names
  • ikky (1)
  • fj33c07
  • nemo (1)
  • wu:fj33c07
  • zgc:113492
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Is predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity. Involved in regulation of I-kappaB kinase/NF-kappaB signaling. Acts upstream of or within I-kappaB phosphorylation and positive regulation of I-kappaB kinase/NF-kappaB signaling. Predicted to be part of IkappaB kinase complex. Is expressed in periderm. Human ortholog(s) of this gene implicated in Behcet's disease; Bloch-Sulzberger syndrome; immunodeficiency 33; and learning disability. Orthologous to human IKBKG (inhibitor of nuclear factor kappa B kinase regulatory subunit gamma).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
8 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Davison et al., 2007
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ikbkg Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Bloch-Sulzberger syndrome Alliance Incontinentia pigmenti 308300
hypohidrotic ectodermal dysplasia Alliance Ectodermal dysplasia and immunodeficiency 1 300291
immunodeficiency 33 Alliance Immunodeficiency 33 300636
Associated With ikbkg Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR021063 NF-kappa-B essential modulator NEMO, N-terminal
Domain IPR032419 NF-kappa-B essential modulator NEMO, CC2-LZ domain
Domain IPR034735 NEMO, Zinc finger
Domain Details Per Protein
Protein Length NEMO, Zinc finger NF-kappa-B essential modulator NEMO, CC2-LZ domain NF-kappa-B essential modulator NEMO, N-terminal
UniProtKB:F1QHM5 586
UniProtKB:F1QHG7 602
UniProtKB:Q58EN3 586
UniProtKB:Q58EP1 506
UniProtKB:Q4G3H3 602
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations