ZFIN is now using GRCz12tu for Genomic Data
Gene
nsd3
- ID
- ZDB-GENE-050324-2
- Name
- nuclear receptor binding SET domain protein 3
- Symbol
- nsd3 Nomenclature History
- Previous Names
-
- whsc1l1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable histone H3K36 methyltransferase activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to act upstream of or within methylation. Predicted to be located in chromosome. Predicted to be active in chromatin and nucleus. Human ortholog(s) of this gene implicated in myeloid leukemia. Orthologous to human NSD3 (nuclear receptor binding SET domain protein 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Sun et al., 2008
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la017439Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la017440Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa7336 | Allele with one point mutation | Unknown | Missense | ENU | |
| sa11365 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa14276 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa16134 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa21713 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa34885 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa38792 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa41639 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-nsd3 | (2) | |
| CRISPR2-nsd3 | LaCoursiere et al., 2024 | |
| CRISPR3-nsd3 | LaCoursiere et al., 2024 | |
| MO1-nsd3 | N/A | (2) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | AWS domain | Histone-lysine N-methyltransferase NSD3, fifth PHD finger | Histone-lysine N-methyltransferase NSD3, first PWWP domain | Histone-lysine N-methyltransferase NSD3, fourth PHD finger | Histone-lysine N-methyltransferase NSD3, second PWWP domain | Histone-lysine N-methyltransferase NSD-like, PHD zinc finger | Histone-lysine N-methyltransferase NSD-like, variant PHD zinc finger | NSD, Cys-His rich domain | Post-SET domain | PWWP domain | SET2 Histone-Lysine N-Methyltransferase | SET domain | SET domain superfamily | Zinc finger, FYVE/PHD-type | Zinc finger, PHD-finger | Zinc finger, PHD-type | Zinc finger, PHD-type, conserved site | Zinc finger, RING/FYVE/PHD-type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2B1N3 | InterPro | 1563 | ||||||||||||||||||
| UniProtKB:A0A8M2B1H9 | InterPro | 1521 | ||||||||||||||||||
| UniProtKB:F1QV68 | InterPro | 1513 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-261P11 | ||
| Contained in | BAC | CH211-113D22 |
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| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021479326 (1) | GRCz12tu | 9459 nt | |
| Genomic | GenBank:BX294119 (1) | 167603 nt | ||
| Polypeptide | UniProtKB:A0A8M2B1N3 (1) | 1563 aa |
- Choi, M.K., Cook, A., Mungikar, K., Eachus, H., Tochwin, A., Linke, M., Gerber, S., Ryu, S. (2024) Exposure to elevated glucocorticoid during development primes altered transcriptional responses to acute stress in adulthood. iScience. 27:110160110160
- LaCoursiere, C.M., Ullmann, J.F.P., Koh, H.Y., Turner, L., Baker, C.M., Robens, B., Shao, W., Rotenberg, A., McGraw, C.M., Poduri, A.H. (2024) Zebrafish models of candidate human epilepsy-associated genes provide evidence of hyperexcitability. iScience. 27:110172110172
- Xu, Y., Guo, R., Huang, T., Guo, C. (2024) miRNA-7145-cuedc2 axis controls hematopoiesis through JAK1/STAT3 signaling pathway. Cell death discovery. 10:209209
- Calvird, A.E., Broniec, M.N., Duval, K.L., Higgs, A.N., Arora, V., Ha, L.N., Schouten, E.B., Crippen, A.R., McGrail, M., Laue, K., Goll, M.G. (2022) Uncovering Regulators of Heterochromatin Mediated Silencing Using a Zebrafish Transgenic Reporter. Frontiers in cell and developmental biology. 10:832461
- Ito, Y., Katayama, K., Nishibori, Y., Akimoto, Y., Kudo, A., Kurayama, R., Hada, I., Takahashi, S., Kimura, T., Fukutomi, T., Katada, T., Suehiro, J., Beltcheva, O., Tryggvason, K., Yan, K. (2017) Wolf-Hirschhorn syndrome candidate 1-like 1 epigenetically regulates nephrin gene expression. American journal of physiology. Renal physiology. 312(6):F1184-F1199
- Yan, S., Lu, Y., He, L., Zhao, X., Wu, L., Zhu, H., Jiang, M., Su, Y., Cao, W., Tian, W., Xing, Q. (2017) Dynamic Editome of Zebrafish under Aminoglycosides Treatment and Its Potential Involvement in Ototoxicity. Frontiers in pharmacology. 8:854
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Yu, C., Zhang, Y., Yao, S., Wei, Y. (2014) A PCR Based Protocol for Detecting Indel Mutations Induced by TALENs and CRISPR/Cas9 in Zebrafish. PLoS One. 9:e98282
- Huang, H.T., Kathrein, K.L., Barton, A., Gitlin, Z., Huang, Y.H., Ward, T.P., Hofmann, O., Dibiase, A., Song, A., Tyekucheva, S., Hide, W., Zhou, Y., and Zon, L.I. (2013) A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nature cell biology. 15(12):1516-1525
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
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