ZFIN is now using GRCz12tu for Genomic Data
Gene
gstm.3
- ID
- ZDB-GENE-050309-24
- Name
- glutathione S-transferase mu tandem duplicate 3
- Symbol
- gstm.3 Nomenclature History
- Previous Names
-
- gstm3 (1)
- im:6897516
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables glutathione transferase activity. Predicted to be involved in glutathione metabolic process. Is expressed in brain; gill; liver; and pleuroperitoneal region. Used to study Brugada syndrome. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung disease (multiple). Orthologous to several human genes including GSTM3 (glutathione S-transferase mu 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Juang et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| Brugada syndrome | gstm.3zf3368/zf3368 | standard conditions | Juang et al., 2020 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004045 | Glutathione S-transferase, N-terminal |
| Domain | IPR004046 | Glutathione S-transferase, C-terminal |
| Domain | IPR010987 | Glutathione S-transferase, C-terminal-like |
| Family | IPR003081 | Glutathione S-transferase, Mu class |
| Family | IPR040079 | Glutathione transferase family |
| Family | IPR050213 | Glutathione S-transferase superfamily |
| Homologous_superfamily | IPR036249 | Thioredoxin-like superfamily |
| Homologous_superfamily | IPR036282 | Glutathione S-transferase, C-terminal domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Glutathione S-transferase, C-terminal | Glutathione S-transferase, C-terminal domain superfamily | Glutathione S-transferase, C-terminal-like | Glutathione S-transferase, Mu class | Glutathione S-transferase, N-terminal | Glutathione S-transferase superfamily | Glutathione transferase family | Thioredoxin-like superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:B8JIS5 | InterPro | 219 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gstm.3-201
(1)
|
Ensembl | 1,603 nt | ||
| mRNA |
gstm.3-203
(1)
|
Ensembl | 1,001 nt | ||
| ncRNA |
gstm.3-003
(1)
|
Ensembl | 1,125 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers