ZFIN is now using GRCz12tu for Genomic Data
Gene
dock7
- ID
- ZDB-GENE-050302-15
- Name
- dedicator of cytokinesis 7
- Symbol
- dock7 Nomenclature History
- Previous Names
-
- fb93h07
- im:7145816
- im:7157388
- wu:fb93h07
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in axonogenesis and regulation of Rho protein signal transduction. Is expressed in central nervous system; optic vesicle; and retina. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 23. Orthologous to human DOCK7 (dedicator of cytokinesis 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7157388 (1 image)
- IMAGE:7157391 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| developmental and epileptic encephalopathy 23 | Alliance | Developmental and epileptic encephalopathy 23 | 615859 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR021816 | Dedicator of cytokinesis C/D, N-terminal |
| Domain | IPR027007 | C2 DOCK-type domain |
| Domain | IPR027357 | DOCKER domain |
| Domain | IPR037808 | Dedicator of cytokinesis C, C2 domain |
| Domain | IPR046769 | DOCKER, Lobe A |
| Domain | IPR046770 | DOCKER, Lobe B |
| Domain | IPR046773 | DOCKER, Lobe C |
| Family | IPR026791 | Dedicator of cytokinesis |
| Homologous_superfamily | IPR035892 | C2 domain superfamily |
| Homologous_superfamily | IPR043161 | Dedicator of cytokinesis, C-terminal, lobe A |
| Homologous_superfamily | IPR043162 | Dedicator of cytokinesis, C-terminal, lobe C |
Domain Details Per Protein
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
dock7-201
(1)
|
Ensembl | 6,938 nt | ||
| mRNA |
dock7-202
(1)
|
Ensembl | 1,225 nt | ||
| mRNA |
dock7-205
(1)
|
Ensembl | 2,811 nt | ||
| mRNA |
dock7-206
(1)
|
Ensembl | 1,814 nt | ||
| mRNA |
dock7-207
(1)
|
Ensembl | 1,941 nt | ||
| mRNA |
dock7-208
(1)
|
Ensembl | 1,410 nt | ||
| ncRNA |
dock7-002
(1)
|
Ensembl | 929 nt | ||
| ncRNA |
dock7-004
(1)
|
Ensembl | 518 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers