ZFIN is now using GRCz12tu for Genomic Data
Gene
ptprc
- ID
- ZDB-GENE-050208-585
- Name
- protein tyrosine phosphatase receptor type C
- Symbol
- ptprc Nomenclature History
- Previous Names
-
- cd45 (1)
- sb:eu845
- si:dkeyp-47c5.1
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in membrane. Is expressed in common myeloid progenitor; epicardium; and hematopoietic system. Human ortholog(s) of this gene implicated in multiple sclerosis; primary immunodeficiency disease; and severe combined immunodeficiency. Orthologous to human PTPRC (protein tyrosine phosphatase receptor type C).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu845 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| severe combined immunodeficiency 105 | Alliance | Immunodeficiency 105, severe combined | 619924 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR016130 | Protein-tyrosine phosphatase, active site |
| Domain | IPR000242 | Tyrosine-specific protein phosphatase, PTPase domain |
| Domain | IPR000387 | Tyrosine-specific protein phosphatases domain |
| Domain | IPR003595 | Protein-tyrosine phosphatase, catalytic |
| Domain | IPR003961 | Fibronectin type III |
| Family | IPR050348 | Protein-Tyrosine Phosphatase |
| Homologous_superfamily | IPR029021 | Protein-tyrosine phosphatase-like |
| Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Fibronectin type III | Fibronectin type III superfamily | Protein-Tyrosine Phosphatase | Protein-tyrosine phosphatase, active site | Protein-tyrosine phosphatase, catalytic | Protein-tyrosine phosphatase-like | Tyrosine-specific protein phosphatase, PTPase domain | Tyrosine-specific protein phosphatases domain |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0AB32THD9 | InterPro | 1425 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers