Gene
acana
- ID
- ZDB-GENE-050208-221
- Name
- aggrecan a
- Symbol
- acana Nomenclature History
- Previous Names
-
- agca
- agc1
- im:7146049
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to have calcium ion binding activity and hyaluronic acid binding activity. Involved in outflow tract morphogenesis. Predicted to localize to extracellular matrix. Is expressed in bulbus arteriosus; cranium; pectoral fin; and pharyngeal arch 3-7. Orthologous to human ACAN (aggrecan).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7146049 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Rambeau et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| osteochondritis dissecans | Alliance | Short stature and advanced bone age, with or without early-onset osteoarthritis and/or osteochondritis dissecans | 165800 |
| spondyloepiphyseal dysplasia Kimberley type | Alliance | ?Spondyloepiphyseal dysplasia, Kimberley type | 608361 |
| Spondyloepimetaphyseal dysplasia, aggrecan type | 612813 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018378 | C-type lectin, conserved site |
| Domain | IPR000436 | Sushi/SCR/CCP domain |
| Domain | IPR000538 | Link domain |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001304 | C-type lectin-like |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Domain | IPR003599 | Immunoglobulin subtype |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR013106 | Immunoglobulin V-set domain |
| Domain | IPR033987 | Aggrecan/versican, C-type lectin-like domain |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR016186 | C-type lectin-like/link domain superfamily |
| Homologous_superfamily | IPR016187 | C-type lectin fold |
| Homologous_superfamily | IPR035976 | Sushi/SCR/CCP superfamily |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Aggrecan/versican, C-type lectin-like domain | C-type lectin, conserved site | C-type lectin fold | C-type lectin-like | C-type lectin-like/link domain superfamily | EGF-like calcium-binding domain | EGF-like domain | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype | Immunoglobulin V-set domain | Link domain | Sushi/SCR/CCP domain | Sushi/SCR/CCP superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q58EI4
|
172 | |||||||||||||||
|
UniProtKB:Q75ZI2
|
287 | |||||||||||||||
|
UniProtKB:F1QDA1
|
1547 | |||||||||||||||
|
UniProtKB:E7F537
|
1509 |
Interactions and Pathways
No data available
Plasmids
No data available