Gene

glsa

ID
ZDB-GENE-050204-3
Name
glutaminase a
Symbol
glsa Nomenclature History
Previous Names
  • glsl
Type
protein_coding_gene
Location
Chr: 22 Mapping Details/Browsers
Description
Predicted to enable glutaminase activity. Predicted to be involved in glutamate biosynthetic process and glutamine catabolic process. Predicted to act upstream of or within glutamine metabolic process. Is expressed in brain; pectoral fin; and swim bladder. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 71. Orthologous to human GLS (glutaminase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With glsa Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
developmental and epileptic encephalopathy 71 Alliance Developmental and epileptic encephalopathy 71 618328
Global developmental delay, progressive ataxia, and elevated glutamine 618412
?Infantile cataract, skin abnormalities, glutamate excess, and impaired intellectual development 618339
Associated With glsa Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR041541 Glutaminase, EF-hand domain
Family IPR015868 Glutaminase
Homologous_superfamily IPR012338 Beta-lactamase/transpeptidase-like
Homologous_superfamily IPR036770 Ankyrin repeat-containing domain superfamily
Repeat IPR002110 Ankyrin repeat
Domain Details Per Protein
Protein Length Ankyrin repeat Ankyrin repeat-containing domain superfamily Beta-lactamase/transpeptidase-like Glutaminase Glutaminase, EF-hand domain
UniProtKB:Q1LWI2 591
UniProtKB:Q1LWI3 298
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations