Gene
glsa
- ID
- ZDB-GENE-050204-3
- Name
- glutaminase a
- Symbol
- glsa Nomenclature History
- Previous Names
-
- glsl
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable glutaminase activity. Predicted to be involved in L-glutamine catabolic process and glutamate biosynthetic process. Predicted to act upstream of or within glutamine metabolic process. Predicted to be located in mitochondrion. Is expressed in brain; pectoral fin; and swim bladder. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 71. Orthologous to human GLS (glutaminase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| developmental and epileptic encephalopathy 71 | Alliance | Developmental and epileptic encephalopathy 71 | 618328 |
| CASGID syndrome | 618339 | ||
| Global developmental delay, progressive ataxia, and elevated glutamine | 618412 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Ankyrin repeat | Ankyrin repeat-containing domain superfamily | Beta-lactamase/transpeptidase-like | Glutaminase | Glutaminase, EF-hand domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2B8I6 | InterPro | 589 | |||||
| UniProtKB:Q1LWI2 | InterPro | 591 | |||||
| UniProtKB:A0A8M3AUM0 | InterPro | 519 | |||||
| UniProtKB:A0A8M9PRT8 | InterPro | 325 | |||||
| UniProtKB:A0AB32TG91 | InterPro | 517 |
Interactions and Pathways
No data available
Plasmids
No data available