Gene
fgf23
- ID
- ZDB-GENE-050201-4
- Name
- fibroblast growth factor 23
- Symbol
- fgf23 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable growth factor activity and type 1 fibroblast growth factor receptor binding activity. Acts upstream of or within calcium ion homeostasis. Predicted to be active in cytoplasm and extracellular space. Is expressed in caudal fin; corpuscles of Stannius; gill; and kidney. Human ortholog(s) of this gene implicated in autosomal dominant hypophosphatemic rickets. Orthologous to human FGF23 (fibroblast growth factor 23).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-fgf23 | Singh et al., 2019 | |
| MO1-fgf23 | N/A | Elizondo et al., 2010 |
| MO2-fgf23 | N/A | Lin et al., 2017 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant hypophosphatemic rickets | Alliance | Hypophosphatemic rickets, autosomal dominant | 193100 |
| Tumoral calcinosis, hyperphosphatemic, familial, 2 | 617993 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cytokine IL1/FGF | Fibroblast growth factor family |
|---|---|---|---|---|
| UniProtKB:Q5MK87 | InterPro | 258 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-240J22 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194106 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194127 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001009564 (1) | 806 nt | ||
| Genomic | GenBank:CR751235 (1) | 104632 nt | ||
| Polypeptide | UniProtKB:Q5MK87 (1) | 258 aa |
- Gjorcheska, S., Paudel, S., McLeod, S., Paulding, D., Snape, L., Sosa, K.C., Duan, C., Kelsh, R., Barske, L. (2025) Sox10 is required for systemic initiation of bone mineralization. Development (Cambridge, England). 152(2):
- Cudak, N., López-Delgado, A.C., Keil, S., Knopf, F. (2023) Fibroblast growth factor pathway component expression in the regenerating zebrafish fin. Gene expression patterns : GEP. 48:119307
- Huang, X., Zhao, X., Zhu, K., Ding, S., Shao, B. (2021) Sodium dehydroacetate induces cardiovascular toxicity associated with Ca2+ imbalance in zebrafish. Ecotoxicology and environmental safety. 208:111613
- Gallegos, T.F., Kamei, C.N., Rohly, M., Drummond, I.A. (2019) Fibroblast growth factor signaling mediates progenitor cell aggregation and nephron regeneration in the adult zebrafish kidney. Developmental Biology. 454(1):44-51
- Singh, A.P., Sosa, M.X., Fang, J., Shanmukhappa, S.K., Hubaud, A., Fawcett, C.H., Molind, G.J., Tsai, T., Capodieci, P., Wetzel, K., Sanchez, E., Wang, G., Coble, M., Tang, W., Cadena, S.M., Fishman, M.C., Glass, D.J. (2019) αKlotho Regulates Age-Associated Vascular Calcification and Lifespan in Zebrafish. Cell Reports. 28:2767-2776.e5
- Laizé, V., Gavaia, P.J., Tarasco, M., Viegas, M.N., Caria, J., Luis, N., Cancela, M.L. (2018) Osteotoxicity of 3-methylcholanthrene in fish. Ecotoxicology and environmental safety. 161:721-728
- Lin, C.H., Hu, H.J., Hwang, P.P. (2017) Molecular physiology of the hypocalcemic action of fibroblast growth factor 23 in zebrafish (Danio rerio). Endocrinology. 158(5):1347-1358
- Rabinowitz, J.S., Robitaille, A.M., Wang, Y., Ray, C.A., Thummel, R., Gu, H., Djukovic, D., Raftery, D., Berndt, J.D., Moon, R.T. (2017) Transcriptomic, proteomic, and metabolomic landscape of positional memory in the caudal fin of zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 114(5):E717-E726
- Suarez-Bregua, P., Saxena, A., Bronner, M.E., Rotllant, J. (2017) Targeted Pth4-expressing cell ablation impairs skeletal mineralization in zebrafish. PLoS One. 12:e0186444
- Suarez-Bregua, P., Torres-Nuñez, E., Saxena, A., Guerreiro, P., Braasch, I., Prober, D.A., Moran, P., Cerda-Reverter, J.M., Du, S.J., Adrio, F., Power, D.M., Canario, A.V., Postlethwait, J.H., Bronner, M.E., Cañestro, C., Rotllant, J. (2017) Pth4, an ancient parathyroid hormone lost in eutherian mammals, reveals a new brain-to-bone signaling pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 31:569-583
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