Gene

ncstn

ID
ZDB-GENE-050131-1
Name
nicastrin
Symbol
ncstn Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to be involved in protein processing. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease; hidradenitis suppurativa; and schizophrenia. Is expressed in several structures, including caudal fin; central nervous system; gill; heart; and otic vesicle. Orthologous to human NCSTN (nicastrin).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from Lim et al., 2015
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ncstn Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hidradenitis suppurativa Alliance Acne inversa, familial, 1 142690
Associated With ncstn Via Experimental Models
Human Disease Fish Conditions Citations
vitiligo ncstnhi1384Tg/hi1384Tg standard conditions Hsu et al., 2019
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR041084 Nicastrin, small lobe
Family IPR008710 Nicastrin
Domain Details Per Protein
Protein Length Nicastrin Nicastrin, small lobe
UniProtKB:Q5XLR3 707
UniProtKB:B3DGT7 707
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations