Gene
gcm2
- ID
- ZDB-GENE-050127-1
- Name
- glial cells missing transcription factor 2
- Symbol
- gcm2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including cartilage development; epidermal cell fate specification; and sodium ion homeostasis. Predicted to be active in nucleus. Is expressed in several structures, including ectoderm; head; macrophage; pharynx; and yolk. Human ortholog(s) of this gene implicated in familial isolated hypoparathyroidism and hyperparathyroidism. Orthologous to human GCM2 (glial cells missing transcription factor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003902 | Transcription regulator GCM domain |
| Family | IPR039791 | Chorion-specific transcription factor GCM |
| Homologous_superfamily | IPR036115 | GCM domain superfamily |
| Homologous_superfamily | IPR043020 | GCM domain, large subdomain |
| Homologous_superfamily | IPR043021 | GCM, small domain |
Domain Details Per Protein
| Protein | Additional Resources | Length | Chorion-specific transcription factor GCM | GCM domain, large subdomain | GCM domain superfamily | GCM, small domain | Transcription regulator GCM domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q68BU9 | InterPro | 496 | |||||
| UniProtKB:Q5TLZ9 | InterPro | 478 |
Interactions and Pathways
No data available
Plasmids
No data available