gcm2

ID

ZDB-GENE-050127-1

Name

glial cells missing transcription factor 2

Symbol

gcm2 Nomenclature History

Previous Names

Gcm-2 (1)
gcmb (1)
mero
merovingian

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including cartilage development; epidermal cell fate specification; and sodium ion homeostasis. Predicted to be active in nucleus. Is expressed in several structures, including ectoderm; head; macrophage; pharynx; and yolk. Human ortholog(s) of this gene implicated in familial isolated hypoparathyroidism and hyperparathyroidism. Orthologous to human GCM2 (glial cells missing transcription factor 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

18 figures from 10 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 9 figures from 7 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gcm2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Hyperparathyroidism 4	617343
		Hypoparathyroidism, familial isolated 2	618883

Associated With gcm2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003902	Transcription regulator GCM domain
Family	IPR039791	Chorion-specific transcription factor GCM
Homologous_superfamily	IPR036115	GCM domain superfamily
Homologous_superfamily	IPR043020	GCM domain, large subdomain
Homologous_superfamily	IPR043021	GCM, small domain