Gene

lss

ID
ZDB-GENE-050119-7
Name
lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
Symbol
lss Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Predicted to have lanosterol synthase activity. Predicted to be involved in cholesterol biosynthetic process. Predicted to localize to lipid droplet. Is expressed in several structures, including heart; integument; liver; pleuroperitoneal region; and skeletal muscle. Human ortholog(s) of this gene implicated in alopecia-mental retardation syndrome; cataract 44; and hypotrichosis 14. Orthologous to human LSS (lanosterol synthase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Anderson et al., 2020
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With lss Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
alopecia-mental retardation syndrome 4 Alliance Alopecia-intellectual disability syndrome 4 618840
cataract 44 Alliance Cataract 44 616509
hypotrichosis 14 Alliance Hypotrichosis 14 618275
Associated With lss Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR002365 Terpene synthase, conserved site
Domain IPR032696 Squalene cyclase, C-terminal
Domain IPR032697 Squalene cyclase, N-terminal
Family IPR018333 Squalene cyclase
Homologous_superfamily IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
Domain Details Per Protein
Protein Length Squalene cyclase Squalene cyclase, C-terminal Squalene cyclase, N-terminal Terpene synthase, conserved site Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
UniProtKB:A4FVM4 735
UniProtKB:B0S5M5 735
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations