Gene
edaradd
- ID
- ZDB-GENE-050114-5
- Name
- EDAR-associated death domain
- Symbol
- edaradd Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Acts upstream of or within embryonic viscerocranium morphogenesis. Predicted to be located in cytoplasm. Is expressed in mouth. Human ortholog(s) of this gene implicated in ectodermal dysplasia 11A and ectodermal dysplasia 11B. Orthologous to human EDARADD (EDAR associated via death domain).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Aigler et al., 2014
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Sadier et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa23062 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-edaradd | N/A | Sadier et al., 2015 |
| MO2-edaradd | N/A | Sadier et al., 2015 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ectodermal dysplasia 11A | Alliance | Ectodermal dysplasia 11A, hypohidrotic/hair/tooth type, autosomal dominant | 614940 |
| ectodermal dysplasia 11B | Alliance | Ectodermal dysplasia 11B, hypohidrotic/hair/tooth type, autosomal recessive | 614941 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Death domain | Death-like domain superfamily | Ectodysplasin-A receptor-associated adapter protein |
|---|---|---|---|---|---|
| UniProtKB:E7F388 | InterPro | 219 | |||
| UniProtKB:A0A8M9PYQ7 | InterPro | 193 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
edaradd-201
(1)
|
Ensembl | 1,887 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-125O16 | ZFIN Curated Data | |
| Encodes | STS | zfish44908-2681g11.p1k |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021474359 (1) | |||
| Genomic | GenBank:BX511245 (1) | 96687 nt | ||
| Polypeptide | UniProtKB:E7F388 (1) | 219 aa |
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Sadier, A., Lambert, E., Chevret, P., Décimo, D., Sémon, M., Tohmé, M., Ruggiero, F., Ohlmann, T., Pantalacci, S., Laudet, V. (2015) Tinkering signaling pathways by gain and loss of protein isoforms: the case of the EDA pathway regulator EDARADD. BMC Evolutionary Biology. 15:129
- Aigler, S.R., Jandzik, D., Hatta, K., Uesugi, K., Stock, D.W. (2014) Selection and constraint underlie irreversibility of tooth loss in cypriniform fishes. Proceedings of the National Academy of Sciences of the United States of America. 111(21):7707-12
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
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