ZFIN is now using GRCz12tu for Genomic Data

Gene

flt3

ID

ZDB-GENE-050114-4

Name

fms related receptor tyrosine kinase 3

Symbol

flt3 Nomenclature History

Previous Names

si:ch211-140b10.8

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Genome Assembly

GRCz11

Annotation Status

Not in current annotation release

Description

Predicted to enable growth factor binding activity and transmembrane receptor protein tyrosine kinase activity. Predicted to be involved in several processes, including B cell differentiation; cell surface receptor signaling pathway; and positive regulation of cell population proliferation. Predicted to be part of signaling receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including ball; digestive system; hematopoietic system; kidney; and pericardial region. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); leukemia (multiple); and prostate cancer. Orthologous to human FLT3 (fms related receptor tyrosine kinase 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Peng et al., 2015
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With flt3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
acute lymphoblastic leukemia	Alliance	Leukemia, acute lymphoblastic, somatic	613065
acute myeloid leukemia	Alliance	Leukemia, acute myeloid, reduced survival in, somatic	601626
acute myeloid leukemia	Alliance	Leukemia, acute myeloid, somatic	601626

Associated With flt3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

No data available

Domain Details Per Protein

No data available

Transcripts

Genome Browsers

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	flt3-201 (1) Ensembl	Ensembl		3,849 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Genome Browsers: No data available

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations