Gene
prox3
- ID
- ZDB-GENE-050107-3
- Name
- prospero homeobox 3
- Symbol
- prox3 Nomenclature History
- Previous Names
-
- prox1b
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within lymphangiogenesis. Predicted to be active in nucleus. Is expressed in axial vasculature; caudal vein plexus; central nervous system; head; and lateral plate mesoderm.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hu3510 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| la025864Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa35 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20900 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-prox3 | N/A | Del Giacco et al., 2010 |
| MO2-prox3 | N/A | Tao et al., 2011 |
| MO3-prox3 | N/A | Tao et al., 2011 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeo-prospero domain | Homeo-prospero domain superfamily | Prospero homeodomain family |
|---|---|---|---|---|---|---|
| UniProtKB:D2DHG1 | InterPro | 659 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
prox1b-201
(1)
|
Ensembl | 3,561 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(prox3:Citrine) |
|
| 1 | (4) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-285J22 | ZFIN Curated Data | |
| Contains | STS | z35725-a1051c06.p1c | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001171587 (1) | 3558 nt | ||
| Genomic | GenBank:CR352261 (1) | 135223 nt | ||
| Polypeptide | UniProtKB:D2DHG1 (1) | 659 aa |
No data available
- Panara, V., Yu, H., Peng, D., Staxäng, K., Hodik, M., Filipek-Gorniok, B., Kazenwadel, J., Skoczylas, R., Mason, E., Allalou, A., Harvey, N.L., Haitina, T., Hogan, B.M., Koltowska, K. (2024) Multiple cis-regulatory elements control prox1a expression in distinct lymphatic vascular beds. Development (Cambridge, England). 151(9):
- Grimm, L., Mason, E., Yu, H., Dudczig, S., Panara, V., Chen, T., Bower, N.I., Paterson, S., Rondon Galeano, M., Kobayashi, S., Senabouth, A., Lagendijk, A.K., Powell, J., Smith, K.A., Okuda, K.S., Koltowska, K., Hogan, B.M. (2023) Single-cell analysis of lymphatic endothelial cell fate specification and differentiation during zebrafish development. The EMBO journal. 42(11):e112590
- Gauvrit, S., Villasenor, A., Strilic, B., Kitchen, P., Collins, M.M., Marín-Juez, R., Guenther, S., Maischein, H.M., Fukuda, N., Canham, M.A., Brickman, J.M., Bogue, C.W., Jayaraman, P.S., Stainier, D.Y.R. (2018) HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development. Nature communications. 9:2704
- Ernens, I., Lumley, A.I., Zhang, L., Devaux, Y., Wagner, D.R. (2017) Hypoxia inhibits lymphatic thoracic duct formation in zebrafish. Biochemical and Biophysical Research Communications. 482(4):1129-1134
- Venero Galanternik, M., Castranova, D., Gore, A.V., Blewett, N.H., Jung, H.M., Stratman, A.N., Kirby, M.R., Iben, J., Miller, M.F., Kawakami, K., Maraia, R.J., Weinstein, B.M. (2017) A novel perivascular cell population in the zebrafish brain. eLIFE. 6
- Yan, H., Zhang, C., Wang, Z., Tu, T., Duan, H., Luo, Y., Feng, J., Liu, F., Yan, X. (2017) CD146 is required for VEGF-C-induced lymphatic sprouting during lymphangiogenesis. Scientific Reports. 7:7442
- Koltowska, K., Lagendijk, A.K., Pichol-Thievend, C., Fischer, J.C., Francois, M., Ober, E.A., Yap, A.S., Hogan, B.M. (2015) Vegfc Regulates Bipotential Precursor Division and Prox1 Expression to Promote Lymphatic Identity in Zebrafish. Cell Reports. 13:1828-41
- Dunworth, W.P., Cardona-Costa, J., Cagavi, E., Kim, J.D., Fischer, J.C., Meadows, S., Wang, Y., Cleaver, O., Qyang, Y., Ober, E.A., and Jin, S.W. (2014) Bone Morphogenetic Protein 2 Signaling Negatively Modulates Lymphatic Development in Vertebrate Embryos. Circulation research. 114(1):56-66
- van Impel, A., Zhao, Z., Hermkens, D.M., Roukens, M.G., Fischer, J.C., Peterson-Maduro, J., Duckers, H., Ober, E.A., Ingham, P.W., and Schulte-Merker, S. (2014) Divergence of zebrafish and mouse lymphatic cell fate specification pathways. Development (Cambridge, England). 141(6):1228-1238
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
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